ANAPC15 and PDE2A

		ANAPC15	PDE2A
Description		anaphase promoting complex subunit 15	phosphodiesterase 2A
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GO Annotations	Cellular Component	Nucleoplasm Anaphase-promoting Complex Cytosol	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Matrix Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Membrane Presynaptic Membrane Perinuclear Region Of Cytoplasm Synaptic Membrane
	Molecular Function	Protein Binding	Nucleotide Binding Magnesium Ion Binding 3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity 3',5'-cGMP-stimulated Cyclic-nucleotide Phosphodiesterase Activity Protein Binding Phosphoric Diester Hydrolase Activity Zinc Ion Binding Hydrolase Activity CAMP Binding CGMP Binding TPR Domain Binding Phosphate Ion Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	Regulation Of Mitotic Cell Cycle Anaphase-promoting Complex-dependent Catabolic Process Cell Division Regulation Of Meiotic Cell Cycle Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Protein Branched Polyubiquitination	Negative Regulation Of Transcription By RNA Polymerase II Heart Valve Development Ventricular Septum Development Signal Transduction Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Gene Expression Regulation Of CGMP-mediated Signaling Negative Regulation Of CGMP-mediated Signaling Regulation Of Mitochondrion Organization CGMP-mediated Signaling Monocyte Differentiation Aorta Development Cellular Response To Macrophage Colony-stimulating Factor Stimulus Negative Regulation Of Vascular Permeability Positive Regulation Of Vascular Permeability CGMP Catabolic Process Positive Regulation Of Inflammatory Response Establishment Of Endothelial Barrier Cellular Response To Mechanical Stimulus Cellular Response To CAMP Cellular Response To CGMP Cellular Response To Xenobiotic Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of CAMP/PKA Signal Transduction Cellular Response To 2,3,7,8-tetrachlorodibenzodioxine
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects	cGMP effects G alpha (s) signalling events
Drugs			Caffeine Cyclic GMP ND7001 ND7001 Exisulind 3-isobutyl-1-methyl-7H-xanthine Tofisopam Doxofylline Trapidil
Diseases
GWAS			Household income (MTAG) ( 31844048) Optic nerve measurement (cup area) ( 20395239) Rheumatoid arthritis ( 22446963)
Interacting Genes		3 interacting genes: ABL1 CDKN2A CEP19	1 interacting genes: ITSN1
Entrez ID		25906	5138
HPRD ID		13172	04041
Ensembl ID		ENSG00000110200	ENSG00000186642
Uniprot IDs		F5GWM6 G5EA39 P60006	O00408 Q8IW54
PDB IDs		4UI9 5A31 5G04 5G05 5L9T 5L9U 5LCW 6Q6G 6Q6H 6TLJ 6TM5 6TNT 8PKP 8TAR 8TAU 9GAW	1Z1L 3IBJ 3ITM 3ITU 4C1I 4D08 4D09 4HTX 4HTZ 4JIB 5TZ3 5TZA 5TZC 5TZH 5TZW 5TZX 5TZZ 5U00 5U7D 5U7I 5U7J 5U7K 5U7L 5VP0 5VP1 5XKM 6B96 6B97 6B98 6BLF 6C7D 6C7E 6C7F 6C7G 6C7I 6C7J 6CYB 6CYC 6CYD 6ZND 6ZQZ
Enriched GO Terms of Interacting Partners?		Mitochondrial Depolarization Negative Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Mitochondrial Membrane Potential Cellular Response To Hydrogen Peroxide Membrane Depolarization Cellular Senescence Response To Transforming Growth Factor Beta Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Protein Ubiquitination Protein Localization To Cytoplasmic Microtubule Plus-end Response To Hydrogen Peroxide Negative Regulation Of Post-translational Protein Modification Cellular Response To Reactive Oxygen Species Ligase Inhibitor Activity Vesicle Targeting, Trans-Golgi To Periciliary Membrane Compartment Regulation Of Cell-matrix Adhesion Negative Regulation Of Catalytic Activity Transitional One Stage B Cell Differentiation Magnesium Ion Binding Response To Reactive Oxygen Species Microspike Assembly Negative Regulation Of Cell-cell Adhesion Cellular Response To Oxygen-containing Compound Regulation Of Protein Ubiquitination Nicotinate-nucleotide Adenylyltransferase Activity Intracellular Signaling Cassette B-1 B Cell Homeostasis Cellular Response To Oxidative Stress Regulation Of Cell-substrate Adhesion Podocyte Apoptotic Process DN4 Thymocyte Differentiation Positive Regulation Of Phospholipase C/protein Kinase C Signal Transduction Cerebellum Morphogenesis Protein Localization To Microtubule Plus-end Regulation Of Lymphocyte Differentiation Phospholipase C-inhibiting G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Establishment Of T Cell Polarity Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress Regulation Of T Cell Differentiation B Cell Proliferation Involved In Immune Response Neuropilin Signaling Pathway Positive Regulation Of Macrophage Apoptotic Process Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Negative Regulation Of Protein Neddylation Ubiquitin-protein Transferase Inhibitor Activity Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Senescence-associated Heterochromatin Focus Negative Regulation Of Immature T Cell Proliferation In Thymus Apoptotic Process Involved In Mammary Gland Involution	Positive Regulation Of Base-excision Repair Regulation Of Base-excision Repair Regulation Of Mitotic Nuclear Division Apoptotic Process Involved In Development Regulation Of Nuclear Division Endocytosis Receptor-mediated Endocytosis Clathrin-dependent Endocytosis Regulation Of DNA Repair Neural Crest Cell Migration Involved In Heart Formation Response To TNF Agonist Oxidized Pyrimidine DNA Binding Brexanolone Catabolic Process Stereocilium Shaft
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