ANAPC15

Description		anaphase promoting complex subunit 15
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GO Annotations	Cellular Component	Nucleoplasm Anaphase-promoting Complex Cytosol
	Molecular Function	Protein Binding
	Biological Process	Regulation Of Mitotic Cell Cycle Anaphase-promoting Complex-dependent Catabolic Process Cell Division Regulation Of Meiotic Cell Cycle Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Protein Branched Polyubiquitination
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects
Drugs
Diseases
GWAS
Novel Interacting Genes		1 novel interacting genes: PDE2A
Interacting Genes		3 interacting genes: ABL1 CDKN2A CEP19
Entrez ID		25906
HPRD ID		13172
Ensembl ID		ENSG00000110200
Uniprot IDs		F5GWM6 G5EA39 P60006
PDB IDs		4UI9 5A31 5G04 5G05 5L9T 5L9U 5LCW 6Q6G 6Q6H 6TLJ 6TM5 6TNT 8PKP 8TAR 8TAU 9GAW
Enriched GO Terms of Interacting Partners?		Mitochondrial Depolarization Negative Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Mitochondrial Membrane Potential Cellular Response To Hydrogen Peroxide Membrane Depolarization Cellular Senescence Response To Transforming Growth Factor Beta Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Protein Ubiquitination Protein Localization To Cytoplasmic Microtubule Plus-end Response To Hydrogen Peroxide Negative Regulation Of Post-translational Protein Modification Cellular Response To Reactive Oxygen Species Ligase Inhibitor Activity Vesicle Targeting, Trans-Golgi To Periciliary Membrane Compartment Regulation Of Cell-matrix Adhesion Negative Regulation Of Catalytic Activity Transitional One Stage B Cell Differentiation Magnesium Ion Binding Response To Reactive Oxygen Species Microspike Assembly Negative Regulation Of Cell-cell Adhesion Cellular Response To Oxygen-containing Compound Regulation Of Protein Ubiquitination Nicotinate-nucleotide Adenylyltransferase Activity Intracellular Signaling Cassette B-1 B Cell Homeostasis Cellular Response To Oxidative Stress Regulation Of Cell-substrate Adhesion Podocyte Apoptotic Process DN4 Thymocyte Differentiation Positive Regulation Of Phospholipase C/protein Kinase C Signal Transduction Cerebellum Morphogenesis Protein Localization To Microtubule Plus-end Regulation Of Lymphocyte Differentiation Phospholipase C-inhibiting G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Establishment Of T Cell Polarity Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress Regulation Of T Cell Differentiation B Cell Proliferation Involved In Immune Response Neuropilin Signaling Pathway Positive Regulation Of Macrophage Apoptotic Process Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Negative Regulation Of Protein Neddylation Ubiquitin-protein Transferase Inhibitor Activity Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Senescence-associated Heterochromatin Focus Negative Regulation Of Immature T Cell Proliferation In Thymus Apoptotic Process Involved In Mammary Gland Involution
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