DEFB116 and ASXL1

		DEFB116	ASXL1
Description		defensin beta 116	ASXL transcriptional regulator 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region	Nucleus Nucleoplasm PR-DUB Complex
	Molecular Function		DNA Binding Chromatin Binding Transcription Coactivator Activity Protein Binding Zinc Ion Binding Nuclear Retinoic Acid Receptor Binding Peroxisome Proliferator Activated Receptor Binding Metal Ion Binding
	Biological Process	Defense Response Defense Response To Bacterium Innate Immune Response	Cell Morphogenesis Heart Morphogenesis Chromatin Organization Regulation Of DNA-templated Transcription Animal Organ Morphogenesis Hemopoiesis Response To Retinoic Acid Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Kidney Size Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Hematopoietic Or Lymphoid Organ Development Thymus Development Bone Marrow Development Homeostasis Of Number Of Cells Bone Development Lung Saccule Development Podocyte Development
Pathways		Beta defensins Defensins	UCH proteinases
Drugs
Diseases			C syndrome, including: Opitz trigonocephaly syndrome; Bohring-Opitz syndrome (BOPS)
GWAS		Prudent dietary pattern ( 28644415) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258)	Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Inflammatory bowel disease ( 28067908) Red cell distribution width ( 32888494)
Interacting Genes			8 interacting genes: APP BAP1 BRD4 FOXK1 GOLGA6L9 SRPK1 STAT3 UBC
Entrez ID		245930	171023
HPRD ID		19020	16516
Ensembl ID		ENSG00000215545	ENSG00000171456
Uniprot IDs		Q30KQ4	A0A2R8Y5U1 Q498B9 Q8IXJ9
PDB IDs			8H1T 8SVF
Enriched GO Terms of Interacting Partners?		Protein O-linked Glycosylation Via Fucose Peptide-O-fucosyltransferase Activity Positive Regulation Of Retinoic Acid Receptor Signaling Pathway PR-DUB Complex Lung Saccule Development Bone Marrow Development Regulation Of Kidney Size Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Fucose Metabolic Process Regulation Of Retinoic Acid Receptor Signaling Pathway Peroxisome Proliferator Activated Receptor Binding Podocyte Development Nuclear Retinoic Acid Receptor Binding Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Segmentation Animal Organ Development Somitogenesis Negative Regulation Of Fat Cell Differentiation Heart Morphogenesis Thymus Development	Neutrophil Differentiation Amyloid-beta Complex Growth Cone Lamellipodium Enzyme Binding Regulation Of Response To Calcium Ion Response To Stress Amylin Binding Positive Regulation Of ATP Metabolic Process Positive Regulation Of Toll Signaling Pathway Regulation Of Inflammatory Response Chromatin Binding Granulocyte Differentiation Fatty Acid Synthase Activity [acyl-carrier-protein] S-acetyltransferase Activity [acyl-carrier-protein] S-malonyltransferase Activity (3R)-hydroxyacyl-[acyl-carrier-protein] Dehydratase Activity Fatty Acyl-[ACP] Hydrolase Activity Phosphopantetheine Binding Spermidine Synthase Activity Nucleate Erythrocyte Differentiation Thrombocyte Differentiation Histone H4K8ac Reader Activity
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