DEFB115 and POFUT1

		DEFB115	POFUT1
Description		defensin beta 115	protein O-fucosyltransferase 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region	Endoplasmic Reticulum Membrane
	Molecular Function	Protein Binding	Transferase Activity Glycosyltransferase Activity Peptide-O-fucosyltransferase Activity
	Biological Process	Defense Response Defense Response To Bacterium Innate Immune Response Defense Response To Gram-negative Bacterium	Angiogenesis Somitogenesis Fucose Metabolic Process Protein Glycosylation Notch Signaling Pathway Nervous System Development Heart Development Regulation Of Notch Signaling Pathway Protein O-linked Glycosylation Via Fucose
Pathways		Beta defensins Defensins	Pre-NOTCH Processing in the Endoplasmic Reticulum
Drugs
Diseases
GWAS		Prudent dietary pattern ( 28644415)	Blood protein levels ( 30072576) Chronic obstructive pulmonary disease ( 28166215) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Inflammatory bowel disease ( 28067908)
Interacting Genes		2 interacting genes: UBQLN1 UBQLN2	4 interacting genes: AKT2 DLL1 JAG1 NOTCH1
Entrez ID		245929	23509
HPRD ID		18944	06319
Ensembl ID		ENSG00000215547	ENSG00000101346
Uniprot IDs		Q30KQ5	Q9H488
PDB IDs			5UX6 5UXH
Enriched GO Terms of Interacting Partners?		Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Autophagosome Regulation Of Response To Endoplasmic Reticulum Stress Autophagosome Assembly ERAD Pathway Autophagosome Organization Negative Regulation Of Store-operated Calcium Channel Activity Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of G Protein-coupled Receptor Internalization Regulation Of Signal Transduction Protein O-linked Glycosylation Via Fucose Peptide-O-fucosyltransferase Activity Positive Regulation Of Proteolysis Vacuole Organization Response To Endoplasmic Reticulum Stress Negative Regulation Of Clathrin-dependent Endocytosis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Macroautophagy Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Retinoic Acid Receptor Signaling Pathway PR-DUB Complex Lung Saccule Development Regulation Of Kidney Size Regulation Of Cell Communication Regulation Of Signaling Bone Marrow Development Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Autophagy Peroxisome Proliferator Activated Receptor Binding Regulation Of Protein Catabolic Process Regulation Of Proteolysis Regulation Of Autophagy Regulation Of Toll-like Receptor 3 Signaling Pathway Podocyte Development Fucose Metabolic Process Aggrephagy Regulation Of Retinoic Acid Receptor Signaling Pathway Negative Regulation Of Transport Negative Regulation Of Receptor Internalization Nuclear Retinoic Acid Receptor Binding Regulation Of Clathrin-dependent Endocytosis Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Proteasomal Protein Catabolic Process Regulation Of Cellular Response To Stress Positive Regulation Of Catabolic Process	Neuron Differentiation Inhibition Of Neuroepithelial Cell Differentiation Regulation Of Timing Of Cell Differentiation Regulation Of Development, Heterochronic Left/right Axis Specification Inner Ear Auditory Receptor Cell Differentiation Hair Cell Differentiation Inner Ear Receptor Cell Differentiation Epidermal Cell Differentiation Nephron Tubule Development Renal Tubule Development Neuronal Stem Cell Population Maintenance Notch Binding Mechanoreceptor Differentiation Tube Morphogenesis Stem Cell Population Maintenance Maintenance Of Cell Number Neuroepithelial Cell Differentiation Distal Tubule Development Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation Negative Regulation Of Inner Ear Receptor Cell Differentiation Compartment Pattern Specification Positive Regulation Of Notch Signaling Pathway Loop Of Henle Development Negative Regulation Of Epithelial Cell Differentiation Epithelial Cell Differentiation Regulation Of Somitogenesis Regulation Of Neuron Differentiation Heart Looping Embryonic Heart Tube Morphogenesis Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Kidney Epithelium Development Negative Regulation Of Neuron Differentiation Epithelium Development Regulation Of Inner Ear Auditory Receptor Cell Differentiation Axis Specification Regulation Of Embryonic Development Nephron Development Determination Of Bilateral Symmetry Determination Of Left/right Symmetry Regulation Of Notch Signaling Pathway Negative Regulation Of Epidermal Cell Differentiation Regulation Of Cell Differentiation Blood Vessel Morphogenesis Notch Signaling Pathway Pulmonary Valve Morphogenesis Epithelial Tube Morphogenesis Morphogenesis Of An Epithelium Cell Differentiation Neuroendocrine Cell Differentiation
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