DEFB115 and ASXL1

		DEFB115	ASXL1
Description		defensin beta 115	ASXL transcriptional regulator 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region	Nucleus Nucleoplasm PR-DUB Complex
	Molecular Function	Protein Binding	DNA Binding Chromatin Binding Transcription Coactivator Activity Protein Binding Zinc Ion Binding Nuclear Retinoic Acid Receptor Binding Peroxisome Proliferator Activated Receptor Binding Metal Ion Binding
	Biological Process	Defense Response Defense Response To Bacterium Innate Immune Response Defense Response To Gram-negative Bacterium	Cell Morphogenesis Heart Morphogenesis Chromatin Organization Regulation Of DNA-templated Transcription Animal Organ Morphogenesis Hemopoiesis Response To Retinoic Acid Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Kidney Size Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Hematopoietic Or Lymphoid Organ Development Thymus Development Bone Marrow Development Homeostasis Of Number Of Cells Bone Development Lung Saccule Development Podocyte Development
Pathways		Beta defensins Defensins	UCH proteinases
Drugs
Diseases			C syndrome, including: Opitz trigonocephaly syndrome; Bohring-Opitz syndrome (BOPS)
GWAS		Prudent dietary pattern ( 28644415)	Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Inflammatory bowel disease ( 28067908) Red cell distribution width ( 32888494)
Interacting Genes		2 interacting genes: UBQLN1 UBQLN2	8 interacting genes: APP BAP1 BRD4 FOXK1 GOLGA6L9 SRPK1 STAT3 UBC
Entrez ID		245929	171023
HPRD ID		18944	16516
Ensembl ID		ENSG00000215547	ENSG00000171456
Uniprot IDs		Q30KQ5	A0A2R8Y5U1 Q498B9 Q8IXJ9
PDB IDs			8H1T 8SVF
Enriched GO Terms of Interacting Partners?		Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Autophagosome Regulation Of Response To Endoplasmic Reticulum Stress Autophagosome Assembly ERAD Pathway Autophagosome Organization Negative Regulation Of Store-operated Calcium Channel Activity Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of G Protein-coupled Receptor Internalization Regulation Of Signal Transduction Protein O-linked Glycosylation Via Fucose Peptide-O-fucosyltransferase Activity Positive Regulation Of Proteolysis Vacuole Organization Response To Endoplasmic Reticulum Stress Negative Regulation Of Clathrin-dependent Endocytosis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Macroautophagy Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Retinoic Acid Receptor Signaling Pathway PR-DUB Complex Lung Saccule Development Regulation Of Kidney Size Regulation Of Cell Communication Regulation Of Signaling Bone Marrow Development Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Autophagy Peroxisome Proliferator Activated Receptor Binding Regulation Of Protein Catabolic Process Regulation Of Proteolysis Regulation Of Autophagy Regulation Of Toll-like Receptor 3 Signaling Pathway Podocyte Development Fucose Metabolic Process Aggrephagy Regulation Of Retinoic Acid Receptor Signaling Pathway Negative Regulation Of Transport Negative Regulation Of Receptor Internalization Nuclear Retinoic Acid Receptor Binding Regulation Of Clathrin-dependent Endocytosis Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Proteasomal Protein Catabolic Process Regulation Of Cellular Response To Stress Positive Regulation Of Catabolic Process	Neutrophil Differentiation Amyloid-beta Complex Growth Cone Lamellipodium Enzyme Binding Regulation Of Response To Calcium Ion Response To Stress Amylin Binding Positive Regulation Of ATP Metabolic Process Positive Regulation Of Toll Signaling Pathway Regulation Of Inflammatory Response Chromatin Binding Granulocyte Differentiation Fatty Acid Synthase Activity [acyl-carrier-protein] S-acetyltransferase Activity [acyl-carrier-protein] S-malonyltransferase Activity (3R)-hydroxyacyl-[acyl-carrier-protein] Dehydratase Activity Fatty Acyl-[ACP] Hydrolase Activity Phosphopantetheine Binding Spermidine Synthase Activity Nucleate Erythrocyte Differentiation Thrombocyte Differentiation Histone H4K8ac Reader Activity
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