MTCH1 and ATP2A3

Data Source: HiPPIP (Novel)

		MTCH1	ATP2A3
Name		mitochondrial carrier 1	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Membrane	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Sarcoplasmic Reticulum Organelle Membrane Platelet Dense Tubular Network Membrane Nuclear Membrane Sarcoplasmic Reticulum Membrane
	Molecular Function	Protein Binding Membrane Insertase Activity	Nucleotide Binding Calcium Channel Regulator Activity P-type Calcium Transporter Activity Protein Binding ATP Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Calcium Ion Transmembrane Transporter Activity ATP Hydrolysis Activity Calcium-dependent ATPase Activity Transmembrane Transporter Binding Metal Ion Binding
	Biological Process	Apoptotic Process Regulation Of Signal Transduction Positive Regulation Of Apoptotic Process Protein Insertion Into Mitochondrial Outer Membrane Neuronal Ion Channel Clustering	Monoatomic Ion Transport Calcium Ion Transport Intracellular Calcium Ion Homeostasis Monoatomic Ion Transmembrane Transport Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Calcium Ion Transmembrane Transport Transport Across Blood-brain Barrier Calcium Ion Transport From Cytosol To Endoplasmic Reticulum Regulation Of Cardiac Conduction
Pathways		None	Pre-NOTCH Processing in Golgi Reduction of cytosolic Ca++ levels Ion homeostasis Ion transport by P-type ATPases
GWAS		Acne (severe) ( 24927181 ) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678 )	Apolipoprotein A1 levels ( 32203549 ) Diastolic blood pressure ( 27841878 ) Glucose homeostasis traits ( 25524916 ) Lung function (FEV1/FVC) ( 30804560 ) Metabolite levels ( 23823483 ) Mild age-related type 2 diabetes ( 34737425 ) Peak expiratory flow ( 30804560 ) Refractive error ( 32231278 )
Novel Interactors		6 novel interactors: ATP2A3 EML4 KCNJ15 LGSN NQO2 ZFAND3	2 novel interactors: CDH16 MTCH1
Interacting Genes		5 interacting genes: APLNR ERBB2 GSK3A PSEN1 UBC	1 interacting genes: IRS1
Entrez ID		23787	489
HPRD ID		14787	03568
Ensembl ID		ENSG00000137409	ENSG00000074370
Uniprot IDs		A0A8Q3WKC8 A8YXX5 H0Y8C3 Q9NZJ7	A8K9K1 Q93084
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Heart Development Negative Regulation Of CAMP-mediated Signaling Negative Regulation Of Muscle Hypertrophy Mechanoreceptor Activity Apelin Receptor Activity Heart Looping Embryonic Heart Tube Morphogenesis Regulation Of Cardiac Muscle Hypertrophy Apelin Receptor Signaling Pathway Negative Regulation Of Cardiac Muscle Hypertrophy Calcium-dependent ATPase Activity Calcium Ion Transport From Cytosol To Endoplasmic Reticulum Apoptotic Signaling Pathway ERBB3:ERBB2 Complex Neuromuscular Junction Negative Regulation Of Cell Development Positive Regulation Of Establishment Of Protein Localization Negative Regulation Of UDP-glucose Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Type B Pancreatic Cell Development Regulation Of Carbohydrate Catabolic Process Negative Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Quinone Catabolic Process Melatonin Binding Oxidoreductase Activity, Acting On Other Nitrogenous Compounds As Donors Dihydronicotinamide Riboside Quinone Reductase Activity Resveratrol Binding Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Cajal-Retzius Cell Differentiation Negative Regulation Of Core Promoter Binding Glutamine Synthetase Activity Glutamine Biosynthetic Process Nitrogen Utilization Positive Regulation Of G Protein-coupled Receptor Internalization RNA Polymerase I Core Binding NAD(P)H Dehydrogenase (quinone) Activity Protein Catabolic Process At Postsynapse Negative Regulation Of Transcription Regulatory Region DNA Binding Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Epithelial Tube Morphogenesis Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of L-glutamate Import Across Plasma Membrane Synaptic Vesicle Targeting Astrocyte Activation Involved In Immune Response	Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Negative Regulation Of Insulin Secretion Regulation Of Fatty Acid Beta-oxidation Signaling Receptor Complex Adaptor Activity Phosphotyrosine Residue Binding Positive Regulation Of Glucose Metabolic Process Phosphatidylinositol 3-kinase Binding Negative Regulation Of Cellular Response To Insulin Stimulus SH2 Domain Binding Positive Regulation Of Cellular Response To Insulin Stimulus Positive Regulation Of Insulin Receptor Signaling Pathway Insulin Receptor Complex Cellular Response To Fatty Acid Positive Regulation Of Lipid Catabolic Process Positive Regulation Of Glycogen Biosynthetic Process Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Peptide Secretion Positive Regulation Of D-glucose Import Protein Kinase C Binding Regulation Of Fatty Acid Oxidation Positive Regulation Of Fatty Acid Beta-oxidation Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of D-glucose Transmembrane Transport Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Positive Regulation Of Fatty Acid Oxidation Regulation Of Glycogen Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Fatty Acid Metabolic Process Neuronal Ion Channel Clustering Membrane Insertase Activity Protein Insertion Into Mitochondrial Outer Membrane Establishment Of Protein Localization To Mitochondrial Membrane Protein Insertion Into Mitochondrial Membrane Response To Fatty Acid Regulation Of Lipid Catabolic Process Regulation Of D-glucose Import