KLHDC2 and ATL1

		KLHDC2	ATL1
Description		kelch domain containing 2	atlastin GTPase 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Body Cullin-RING Ubiquitin Ligase Complex Cul2-RING Ubiquitin Ligase Complex Nuclear Membrane	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Axon Cell Projection Endoplasmic Reticulum Tubular Network Endoplasmic Reticulum Tubular Network Membrane Endoplasmic Reticulum Subcompartment Golgi Cis Cisterna Membrane
	Molecular Function	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity Identical Protein Binding GTPase-dependent Fusogenic Activity
	Biological Process	Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway	Endoplasmic Reticulum Organization Axonogenesis Endoplasmic Reticulum Membrane Fusion Protein Homooligomerization Endoplasmic Reticulum Tubular Network Membrane Organization
Pathways
Drugs
Diseases			Hereditary spastic paraplegia (SPG)
GWAS			Cognitive performance ( 20125193) Dupuytren's disease ( 28886342) Femur bone mineral density x serum urate levels interaction ( 34046847) Periodontal disease-related phenotype (Socransky) ( 24347629)
Interacting Genes		8 interacting genes: EZH2 NEDD8 RBX1 RIC8B SELENOK SELENOS STRN4 USP1	1 interacting genes: SYVN1
Entrez ID		23588	51062
HPRD ID		08824	05918
Ensembl ID		ENSG00000165516	ENSG00000198513
Uniprot IDs		Q9Y2U9	A0A0S2Z5A2 A0A0S2Z5B0 Q53F53 Q8WXF7
PDB IDs		6DO3 6DO4 6DO5 8EBL 8EBM 8EBN 8PIF 8SGE 8SGF 8SH2 8UXS 9BC9 9BCA 9BCC	3Q5D 3Q5E 3QNU 3QOF 4IDN 4IDO 4IDP 4IDQ 6B9D 6B9E 6B9F 6B9G 6XJN 7OL3
Enriched GO Terms of Interacting Partners?		Response To Oxidative Stress Protein Modification Process Hepatocyte Homeostasis Cellular Response To Stress Cellular Response To Oxidative Stress Protein Neddylation Positive Regulation Of Error-prone Translesion Synthesis Cell Redox Homeostasis Response To Endoplasmic Reticulum Stress Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Endoplasmic Reticulum Subcompartment Cellular Response To Chemical Stress	Nucleoplasm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cullin-RING Ubiquitin Ligase Complex Proteasomal Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway Cul2-RING Ubiquitin Ligase Complex Microtubule Anchoring At Centrosome Collateral Sprouting Corticospinal Tract Morphogenesis Ciliary Basal Body Centriolar Subdistal Appendage Ciliary Transition Fiber Centriole-centriole Cohesion Microtubule Nucleation By Microtubule Organizing Center Microtubule Minus-end Binding Corpus Callosum Morphogenesis Centrosome-templated Microtubule Nucleation Microtubule Anchoring At Microtubule Organizing Center Dynein Axonemal Particle Regulation Of Protein Stability Outer Dynein Arm Assembly Establishment Of Left/right Asymmetry Protein Stabilization Inner Dynein Arm Assembly Hrd1p Ubiquitin Ligase ERAD-L Complex Retrograde Protein Transport, ER To Cytosol Protein Alpha-1,2-demannosylation Negative Regulation Of T-helper 1 Type Immune Response Endoplasmic Reticulum Mannose Trimming Smooth Endoplasmic Reticulum Immature B Cell Differentiation Ubiquitin-specific Protease Binding Hrd1p Ubiquitin Ligase Complex Derlin-1 Retrotranslocation Complex Protein Deglycosylation Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Axonal Growth Cone Pericentriolar Material Central Nervous System Projection Neuron Axonogenesis Microtubule Anchoring Endoplasmic Reticulum Quality Control Compartment Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Catabolic Process Protein Ubiquitination Microtubule Nucleation Central Nervous System Neuron Axonogenesis Centrosome Localization Protein Folding Chaperone Complex Protein Exit From Endoplasmic Reticulum
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