KCNH3 and GNAL

		KCNH3	GNAL
Description		potassium voltage-gated channel subfamily H member 3	G protein subunit alpha L
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Monoatomic Ion Channel Complex	Cytoplasm Heterotrimeric G-protein Complex Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Monoatomic Ion Channel Activity Inward Rectifier Potassium Channel Activity Voltage-gated Potassium Channel Activity Potassium Channel Activity Protein Binding	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Adenylate Cyclase Regulator Activity Hydrolase Activity Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Monoatomic Ion Transmembrane Transport Regulation Of Membrane Potential Transmembrane Transport Potassium Ion Transmembrane Transport	Response To Amphetamine Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Sensory Perception Of Chemical Stimulus Sensory Perception Of Smell Response To Caffeine
Pathways		Voltage gated Potassium channels	Adenylate cyclase activating pathway Adenylate cyclase inhibitory pathway Olfactory Signaling Pathway Olfactory Signaling Pathway
Drugs		Enflurane Promethazine Miconazole
Diseases
GWAS		Age at first birth ( 34211149) Intelligence (MTAG) ( 29326435)	Age at first sexual intercourse ( 27089180) Alcohol dependence ( 26365420) Metabolite levels ( 23823483) QT interval (drug interaction) ( 23459443) Sensation seeking ( 30718321) Tandem gait ( 26219847) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes
Entrez ID		23416	2774
HPRD ID		05164	00758
Ensembl ID		ENSG00000135519	ENSG00000141404
Uniprot IDs		Q9ULD8	A8K1Y9 P38405
PDB IDs			8EL8 8IW1 8KGK 8KH4
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase Regulator Activity Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Response To Caffeine G Protein-coupled Dopamine Receptor Signaling Pathway Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Response To Amphetamine Heterotrimeric G-protein Complex Response To Amine Sensory Perception Of Smell G Protein-coupled Receptor Binding G Protein Activity Response To Alkaloid Sensory Perception Of Chemical Stimulus Response To Purine-containing Compound Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway GTPase Activity GTP Binding	Negative Regulation Of Leukocyte Migration Negative Regulation Of Mononuclear Cell Migration Negative Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Endocytosis Membrane Raft Polarization Myeloid Dendritic Cell Activation Involved In Immune Response Regulation Of Mononuclear Cell Migration Phenylpyruvate Tautomerase Activity Positive Regulation Of Arachidonate Secretion Positive Regulation Of Prostaglandin Secretion Involved In Immune Response Regulation Of Signal Transduction By P53 Class Mediator Dopachrome Isomerase Activity Negative Regulation Of Mature B Cell Apoptotic Process Negative Regulation Of Membrane Tubulation Positive Regulation Of Clathrin-dependent Endocytosis Actin Cap Negative Regulation Of Lysosomal Protein Catabolic Process Positive Regulation Of Amyloid Fibril Formation Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Positive T Cell Selection Positive Regulation Of Cellular Component Organization Membrane Raft Distribution Positive Thymic T Cell Selection T Cell Receptor Binding Positive Regulation Of Transport Locomotion Immunological Synapse Formation Small GTPase-mediated Signal Transduction Alpha-beta T Cell Proliferation Actin Cytoskeleton Organization Pinocytosis Macropinocytosis Negative Thymic T Cell Selection Negative T Cell Selection Membrane Raft Localization Plasma Membrane Chemotaxis Regulation Of Endocytosis Establishment Of T Cell Polarity Regulation Of Leukocyte Migration Prostaglandin Biosynthetic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Prostanoid Biosynthetic Process Regulation Of Arachidonate Secretion Negative Regulation Of B Cell Apoptotic Process Negative Regulation Of Macrophage Migration Positive Regulation Of Icosanoid Secretion Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Macrophage Chemotaxis Protein Homotrimerization
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