EXOC6B and MOGS

		EXOC6B	MOGS
Description		exocyst complex component 6B	mannosyl-oligosaccharide glucosidase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Exocyst Plasma Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Extracellular Exosome
	Molecular Function	Protein Binding	Glc3Man9GlcNAc2 Oligosaccharide Glucosidase Activity Glucosidase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds
	Biological Process	Mitotic Cytokinesis Intracellular Protein Transport Exocytosis Golgi To Plasma Membrane Transport Vesicle Docking Involved In Exocytosis Protein Transport Membrane Fission Vesicle Tethering Involved In Exocytosis	Carbohydrate Metabolic Process Protein Folding Protein N-linked Glycosylation Oligosaccharide Metabolic Process Viral Protein Processing
Pathways			Defective MOGS causes CDG-2b N-glycan trimming in the ER and Calnexin/Calreticulin cycle Maturation of spike protein Maturation of spike protein Regulation of CDH1 posttranslational processing and trafficking to plasma membrane
Drugs
Diseases			Congenital disorders of glycosylation (CDG) type II
GWAS		Appendicular lean mass ( 33097823) Diastolic blood pressure ( 27841878 30224653) Height ( 31562340) Malaria ( 31844061) Serum metabolite levels ( 33031748) Severe autoimmune type 2 diabetes ( 34737425) Systolic blood pressure ( 27841878)
Interacting Genes		3 interacting genes: MTERF1 RALA SHTN1	1 interacting genes: CHGB
Entrez ID		23233	7841
HPRD ID		19418	03214
Ensembl ID		ENSG00000144036	ENSG00000115275
Uniprot IDs		A0A0U1RRB6 Q9Y2D4	A0A384MDR6 Q13724 Q58F09
PDB IDs
Enriched GO Terms of Interacting Partners?		Ras Protein Signal Transduction Glucosidase Activity Glc3Man9GlcNAc2 Oligosaccharide Glucosidase Activity Endoplasmic Reticulum Polarization Actin Filament Bundle Retrograde Transport Edg-2 Lysophosphatidic Acid Receptor Binding Termination Of Mitochondrial Transcription Cdc42 Protein Signal Transduction Intracellular Signaling Cassette NF-kappaB Complex Cytoplasmic Actin-based Contraction Involved In Cell Motility Small GTPase-mediated Signal Transduction Membrane Raft Localization DNA Geometric Change Netrin-activated Signaling Pathway
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