CEP68 and AAK1

		CEP68	AAK1
Description		centrosomal protein 68	AP2 associated kinase 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Cell Junction Centriolar Satellite Ciliary Basal Body	Cytosol Plasma Membrane Clathrin-coated Pit Membrane Clathrin-coated Vesicle Cell Leading Edge Cell Projection Terminal Bouton Synapse Presynapse
	Molecular Function	Protein Binding Protein Kinase Binding Protein Domain Specific Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Notch Binding Protein Binding ATP Binding Kinase Activity Transferase Activity AP-2 Adaptor Complex Binding Protein Serine Kinase Activity
	Biological Process	Centrosome Cycle Centriole-centriole Cohesion Protein Localization To Organelle	Protein Phosphorylation Endocytosis Regulation Of Protein Localization Positive Regulation Of Notch Signaling Pathway Protein Stabilization Membrane Organization Presynaptic Endocytosis Regulation Of Clathrin-dependent Endocytosis
Pathways			Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs			Fostamatinib
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Atrial fibrillation ( 33990960 28416818 28416822 30061737 29892015) HDL cholesterol levels ( 32203549) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Metabolic syndrome ( 31589552) Platelet distribution width ( 32888494) Pulse pressure ( 30578418 28135244 27841878) Systolic blood pressure ( 30578418 27841878) Triglyceride levels ( 32203549) Triglycerides ( 30275531 25961943) Type 2 diabetes ( 30054458 29632382 30297969) Type 2 diabetes (adjusted for BMI) ( 29632382) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408)	Dentures ( 31235808) Hematocrit ( 32888494) Hemoglobin ( 32888494) Metabolite levels (Dihydroxy docosatrienoic acid) ( 23934736) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Parkinson's disease (age of onset) ( 19772629) Serum thyroid-stimulating hormone levels ( 25436638) Urate levels ( 31578528)
Interacting Genes		9 interacting genes: COG2 CTBP1 CTBP2 HGS MCM7 TRAF3IP3 TRIM54 TSNAX USHBP1	1 interacting genes: APP
Entrez ID		23177	22848
HPRD ID		13808	10620
Ensembl ID		ENSG00000011523	ENSG00000115977
Uniprot IDs		A0A994J4E5 Q76N32	E9PG46 Q2M2I8
PDB IDs			4WSQ 5L4Q 5TE0 8GMC 8GMD
Enriched GO Terms of Interacting Partners?		White Fat Cell Differentiation Viral Genome Replication Presynaptic Endocytosis NAD Binding Transcription Coregulator Binding Transcription Corepressor Binding Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Heparan Sulfate Proteoglycan Binding Acetylcholine Receptor Binding Golgi-associated Vesicle Insulin Receptor Binding Apolipoprotein Binding Response To Lead Ion Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel High-density Lipoprotein Particle Very-low-density Lipoprotein Particle Neuron Projection Maintenance RAGE Receptor Binding
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