AAK1

Description		AP2 associated kinase 1
Image
GO Annotations	Cellular Component	Cytosol Plasma Membrane Clathrin-coated Pit Membrane Clathrin-coated Vesicle Cell Leading Edge Cell Projection Terminal Bouton Synapse Presynapse
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Notch Binding Protein Binding ATP Binding Kinase Activity Transferase Activity AP-2 Adaptor Complex Binding Protein Serine Kinase Activity
	Biological Process	Protein Phosphorylation Endocytosis Regulation Of Protein Localization Positive Regulation Of Notch Signaling Pathway Protein Stabilization Membrane Organization Presynaptic Endocytosis Regulation Of Clathrin-dependent Endocytosis
Pathways		Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs		Fostamatinib
Diseases
GWAS		Dentures ( 31235808) Hematocrit ( 32888494) Hemoglobin ( 32888494) Metabolite levels (Dihydroxy docosatrienoic acid) ( 23934736) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Parkinson's disease (age of onset) ( 19772629) Serum thyroid-stimulating hormone levels ( 25436638) Urate levels ( 31578528)
Novel Interacting Genes		1 novel interacting genes: CEP68
Interacting Genes		1 interacting genes: APP
Entrez ID		22848
HPRD ID		10620
Ensembl ID		ENSG00000115977
Uniprot IDs		E9PG46 Q2M2I8
PDB IDs		4WSQ 5L4Q 5TE0 8GMC 8GMD
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Heparan Sulfate Proteoglycan Binding Acetylcholine Receptor Binding Golgi-associated Vesicle Insulin Receptor Binding Apolipoprotein Binding Response To Lead Ion Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel High-density Lipoprotein Particle Very-low-density Lipoprotein Particle Neuron Projection Maintenance RAGE Receptor Binding
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