EMC1 and TTC27

		EMC1	TTC27
Description		ER membrane protein complex subunit 1	tetratricopeptide repeat domain 27
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Protein-containing Complex EMC Complex
	Molecular Function	Protein Binding Membrane Insertase Activity	Protein Binding
	Biological Process	Protein Insertion Into ER Membrane By Stop-transfer Membrane-anchor Sequence Tail-anchored Membrane Protein Insertion Into ER Membrane
Pathways
Drugs
Diseases
GWAS			Age at first sexual intercourse ( 34211149) Appendicular lean mass ( 33097823) Haemorrhoidal disease ( 33888516) Hippocampal atrophy ( 22745009) Intelligence (MTAG) ( 29326435) Male-pattern baldness ( 28196072) Metabolite levels ( 23823483) Number of sexual partners ( 30643258) Rosacea symptom severity ( 29771307) Upper eyelid sagging severity ( 24869959)
Interacting Genes			8 interacting genes: ACVR1 BMPR1B CRYAA DAPK1 ITSN1 LRRK2 MFHAS1 TGFBR1
Entrez ID		23065	55622
HPRD ID		08306	08618
Ensembl ID		ENSG00000127463	ENSG00000018699
Uniprot IDs		H7C5A2 Q8N766	B4DRC7 Q6P3X3
PDB IDs		6WW7 6Z3W 7ADO 7ADP 8EOI 8J0N 8J0O 8S9S 9C7V
Enriched GO Terms of Interacting Partners?			Transforming Growth Factor Beta Receptor Activity, Type I Transmembrane Receptor Protein Serine/threonine Kinase Activity Protein Serine/threonine Kinase Activity SMAD Binding Protein Kinase Activity Activin Receptor Complex Activin Receptor Activity, Type I Kinase Activity BMP Receptor Activity Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Activin Binding Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Process Pharyngeal System Development Negative Regulation Of Programmed Cell Death Syntaxin-1 Binding Transforming Growth Factor Beta Binding Nucleotide Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Activin Receptor Signaling Pathway Cellular Response To BMP Stimulus Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Programmed Cell Death Regulation Of Signal Transduction Response To Stress Ventricular Septum Morphogenesis Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Bone Mineralization Lens Development In Camera-type Eye Growth Factor Binding Cellular Response To Growth Factor Stimulus ATP Binding Regulation Of Cell Communication Positive Regulation Of Biomineral Tissue Development Regulation Of Signaling Regionalization Regulation Of Chondrocyte Differentiation Positive Regulation Of Ossification Animal Organ Development Regulation Of Macrophage Activation Negative Regulation Of Intracellular Transport Anatomical Structure Morphogenesis Endocardial Cushion Cell Fate Commitment Dorsal/ventral Pattern Formation
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