EMC1 and PCP4

		EMC1	PCP4
Description		ER membrane protein complex subunit 1	Purkinje cell protein 4
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Protein-containing Complex EMC Complex	Nucleus Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	Protein Binding Membrane Insertase Activity	Calcium Ion Binding Protein Binding Calmodulin Binding
	Biological Process	Protein Insertion Into ER Membrane By Stop-transfer Membrane-anchor Sequence Tail-anchored Membrane Protein Insertion Into ER Membrane	Positive Regulation Of Neuron Differentiation Positive Regulation Of CAMKK-AMPK Signaling Cascade
Pathways
Drugs
Diseases
GWAS			Asthma ( 32296059) Metabolite levels ( 23823483) Systolic blood pressure (alcohol consumption interaction) ( 24376456) Venlafaxine response in generalised anxiety disorder (responders vs non-responders after 12 weeks) ( 28437668)
Interacting Genes			7 interacting genes: CALM1 CALML6 DAPK1 PAX6 POT1 TERF1 TERF2IP
Entrez ID		23065	5121
HPRD ID		08306	03378
Ensembl ID		ENSG00000127463	ENSG00000183036
Uniprot IDs		H7C5A2 Q8N766	P48539
PDB IDs		6WW7 6Z3W 7ADO 7ADP 8EOI 8J0N 8J0O 8S9S 9C7V	2N77
Enriched GO Terms of Interacting Partners?			Shelterin Complex Nuclear Telomere Cap Complex G-rich Strand Telomeric DNA Binding Telomere Capping Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Telomeric DNA Binding Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Metabolic Process Negative Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Telomeric D-loop Disassembly Negative Regulation Of Chromosome Organization Telomeric Loop Disassembly DNA Biosynthetic Process Telomere Maintenance Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Telomere Organization Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Chromosome, Telomeric Region Regulation Of DNA Metabolic Process Regulation Of Telomere Maintenance Via Telomerase DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Negative Regulation Of Endodeoxyribonuclease Activity Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Negative Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Regulation Of Chromosome Organization Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Positive Regulation Of DNA Metabolic Process Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cellular Response To Type II Interferon Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Negative Regulation Of Deoxyribonuclease Activity Cytotoxic T Cell Pyroptotic Cell Death Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Positive Regulation Of Telomeric Loop Disassembly
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