TMCC1 and PLXND1

		TMCC1	PLXND1
Description		transmembrane and coiled-coil domain family 1	plexin D1
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Cytosol Endomembrane System Membrane Endoplasmic Reticulum-endosome Membrane Contact Site	Semaphorin Receptor Complex Plasma Membrane Membrane Lamellipodium Axon Lamellipodium Membrane Cell Projection Cell Body Glutamatergic Synapse Plasma Membrane Bounded Cell Projection
	Molecular Function	Protein Binding Identical Protein Binding	Protein Binding Semaphorin Receptor Activity Protein Domain Specific Binding
	Biological Process	Endoplasmic Reticulum Organization Endosomal Transport Membrane Fission Endosome Membrane Tubulation Endosome Fission	Angiogenesis Branching Involved In Blood Vessel Morphogenesis Kidney Development Outflow Tract Morphogenesis Cardiac Septum Development Negative Regulation Of Cell Adhesion Synapse Assembly Synaptic Target Recognition Regulation Of Cell Shape Regulation Of Cell Migration Aorta Development Negative Regulation Of Neuron Apoptotic Process Endothelial Cell Migration Regulation Of Angiogenesis Positive Regulation Of Axonogenesis Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Coronary Vasculature Development Semaphorin-plexin Signaling Pathway
Pathways			Other semaphorin interactions NOTCH3 Intracellular Domain Regulates Transcription RND2 GTPase cycle
Drugs
Diseases
GWAS		A body shape index ( 34021172) Breast size ( 22747683) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Type 2 diabetes ( 30297969) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	A body shape index ( 34021172) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 25673412 34021172) Hip index ( 34021172) Low density lipoprotein cholesterol levels ( 32154731) Mean platelet volume ( 32888494) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI ( 34021172 26426971) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 28448500 25673412)
Interacting Genes		2 interacting genes: APP ZDHHC17	3 interacting genes: HOXB5 MACF1 SEMA4A
Entrez ID		23023	23129
HPRD ID		15518	05046
Ensembl ID		ENSG00000172765	ENSG00000004399
Uniprot IDs		A0A8V8TLJ9 E9PC87 O94876 Q6N039	Q9Y4D7
PDB IDs			3H6N
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Cell Recognition Cell Body Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Neuron Recognition Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Axonogenesis Negative Regulation Of Intralumenal Vesicle Formation Epidermal Growth Factor Catabolic Process Neurotransmitter Receptor Transport, Postsynaptic Endosome To Lysosome Lipophagy Glutamatergic Synapse Synaptic Vesicle Recycling Via Endosome Synaptic Target Recognition Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Perforant Pathway To Dendrate Granule Cell Synapse Medium-chain Fatty Acyl-CoA Dehydrogenase Activity Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Cytoplasmic Vesicle Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Mitochondrial Membrane Negative Regulation Of Exosomal Secretion Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Long-chain Fatty Acyl-CoA Dehydrogenase Activity Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Protein Catabolic Process Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Protein To Membrane Docking Regulation Of Endosome Organization
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