ITGA11 and NDST1

		ITGA11	NDST1
Description		integrin subunit alpha 11	N-deacetylase and N-sulfotransferase 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion Integrin Complex Cell Surface Membrane Integrin Alpha11-beta1 Complex	Golgi Membrane Golgi Apparatus Membrane Trans-Golgi Network Membrane
	Molecular Function	Collagen Binding Signaling Receptor Activity Collagen Receptor Activity Metal Ion Binding Collagen Binding Involved In Cell-matrix Adhesion	Catalytic Activity Protein Binding Sulfotransferase Activity Heparan Sulfate N-sulfotransferase Activity Transferase Activity Hydrolase Activity Deacetylase Activity N-acetylglucosamine Deacetylase Activity Heparan Sulfate N-deacetylase Activity
	Biological Process	Osteoblast Differentiation Substrate-dependent Cell Migration Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Muscle Organ Development Cell Adhesion Mediated By Integrin Collagen-activated Signaling Pathway Cell-cell Adhesion	Polysaccharide Biosynthetic Process Cardiac Septum Development Inflammatory Response Heart Development Respiratory Gaseous Exchange By Respiratory System Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Animal Organ Morphogenesis Heparan Sulfate Proteoglycan Biosynthetic Process Glycosaminoglycan Metabolic Process Heparin Proteoglycan Biosynthetic Process Forebrain Development Midbrain Development Aorta Development Positive Regulation Of MAPK Cascade Positive Regulation Of Smoothened Signaling Pathway Embryonic Neurocranium Morphogenesis Embryonic Viscerocranium Morphogenesis Coronary Vasculature Development
Pathways		Integrin cell surface interactions Integrin cell surface interactions	HS-GAG biosynthesis
Drugs			Adenosine 3',5'-diphosphate
Diseases
GWAS		Attention deficit hyperactivity disorder ( 18839057) Dupuytren's disease ( 28886342) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Major depressive disorder ( 23377640) Perceived intensity of fructose ( 31005972) Systolic blood pressure ( 26969751)	Appendicular lean mass ( 33097823) Blood protein levels ( 30072576) Cholangiocarcinoma in primary sclerosing cholangitis ( 28779025) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Neutrophil count ( 32888494)
Interacting Genes		1 interacting genes: ITGB1	2 interacting genes: LCOR RUNX1
Entrez ID		22801	3340
HPRD ID		05310	02912
Ensembl ID		ENSG00000137809	ENSG00000070614
Uniprot IDs		B3KTN6 Q9UKX5	A8K8T3 P52848
PDB IDs			1NST 8CCY 8CD0 8CHS
Enriched GO Terms of Interacting Partners?		Heparan Sulfate N-sulfotransferase Activity Heparan Sulfate N-deacetylase Activity N-acetylglucosamine Deacetylase Activity Myoblast Fate Specification Integrin Alpha6-beta1 Complex Positive Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Integrin Alpha8-beta1 Complex Integrin Alpha1-beta1 Complex Integrin Alpha5-beta1 Complex Integrin Alpha10-beta1 Complex Integrin Alpha7-beta1 Complex Integrin Alphav-beta1 Complex Integrin Alpha11-beta1 Complex Cardiac Cell Fate Specification Integrin Alpha3-beta1 Complex Integrin Alpha9-beta1 Complex Integrin Alpha4-beta1 Complex Integrin Alpha2-beta1 Complex Positive Regulation Of L-glutamate Import Across Plasma Membrane Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Calcium-independent Cell-matrix Adhesion Regulation Of Collagen Catabolic Process Formation Of Radial Glial Scaffolds C-X3-C Chemokine Binding Integrin Binding Involved In Cell-matrix Adhesion Myelin Sheath Abaxonal Region Collagen Binding Involved In Cell-matrix Adhesion Regulation Of Spontaneous Synaptic Transmission Reactive Gliosis Positive Regulation Of Neurotransmitter Uptake Heparin Proteoglycan Biosynthetic Process Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Cerebellar Climbing Fiber To Purkinje Cell Synapse Cell-cell Adhesion Mediated By Integrin Embryonic Neurocranium Morphogenesis Germ Cell Migration Inflammatory Response Regulation Of L-glutamate Import Across Plasma Membrane Deacetylase Activity Embryonic Viscerocranium Morphogenesis Regulation Of Synapse Pruning CD40 Signaling Pathway Cardiac Muscle Cell Myoblast Differentiation Heparin Proteoglycan Metabolic Process Enzyme-linked Receptor Protein Signaling Pathway Negative Regulation Of Vasoconstriction Cardioblast Differentiation Cell Population Proliferation Neuroinflammatory Response Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway
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