DHRSX and FADS3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DHRSX	FADS3
Description		dehydrogenase/reductase X-linked	fatty acid desaturase 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Lipid Droplet	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Binding Oxidoreductase Activity Polyprenol Dehydrogenase (NAD+) Activity Dolichal Reductase (NADPH) Activity	Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Oxidation Of A Pair Of Donors Resulting In The Reduction Of Molecular Oxygen To Two Molecules Of Water
	Biological Process	Positive Regulation Of Autophagy Dolichyl Monophosphate Biosynthetic Process	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Unsaturated Fatty Acid Biosynthetic Process Sphingolipid Metabolic Process Gene Expression
Pathways		Synthesis of dolichyl-phosphate
Drugs
Diseases
GWAS			Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Asthma (adult onset) ( 31036433) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Cholesterol, total ( 24097068 19060911 20686565 25961943) Fatty acid desaturase activity (serum) ( 30453627) Glycated hemoglobin levels ( 34059833) HDL cholesterol ( 25961943 20686565 19060906 19060911 24097068) HDL cholesterol levels ( 28334899) Laryngeal squamous cell carcinoma ( 25194280) LDL cholesterol ( 20686565 25961943 19060911 24097068) LDL cholesterol levels ( 28334899) Lipid metabolism phenotypes ( 22286219) Metabolite levels ( 23378610 22916037 23823483) Oleic acid (18:1n-9) levels ( 23362303) Phospholipid levels (plasma) ( 22359512) Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) ( 21829377) Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid) ( 21829377) Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377) Plasma omega-6 polyunsaturated fatty acid levels (adrenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311) Red blood cell fatty acid levels ( 25500335) Response to statin therapy ( 20339536) Rheumatoid arthritis ( 30423114 24390342) Serum metabolite levels (CMS) ( 31636271) Sphingolipid d18:1/d18:2 ratio ( 31862735) Sphingolipid levels ( 22359512 19798445) Stearic acid (18:0) levels ( 23362303) Total cholesterol levels ( 28334899) Triglyceride levels ( 28334899) Triglycerides ( 25961943 24097068 20686565 19060906) Urate levels ( 31578528)
Interacting Genes		20 interacting genes: APOC1 APP AQP6 ASPH ATXN1 CIDEB CMTM5 FADS3 GCNT3 HSD17B11 PGRMC2 PIGP RETREG3 RUSF1 TLCD4 TMEM143 TMEM14B TMEM31 TMEM86B ZDHHC15	1 interacting genes: DHRSX
Entrez ID		207063	3995
HPRD ID		16803	07547
Ensembl ID		ENSG00000169084	ENSG00000221968
Uniprot IDs		Q8N5I4	E9PKP8 Q9Y5Q0
PDB IDs
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Membrane Very-low-density Lipoprotein Particle Assembly	Dolichal Reductase (NADPH) Activity Polyprenol Dehydrogenase (NAD+) Activity Dolichyl Monophosphate Biosynthetic Process Ribosomal Large Subunit Assembly
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