ANO6 and CPNE8

		ANO6	CPNE8
Description		anoctamin 6	copine 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Cell Surface Membrane Monoatomic Ion Channel Complex Chloride Channel Complex Specific Granule Membrane Extracellular Exosome Tertiary Granule Membrane	Plasma Membrane Extracellular Exosome
	Molecular Function	Calcium-activated Cation Channel Activity Intracellularly Calcium-gated Chloride Channel Activity Voltage-gated Monoatomic Ion Channel Activity Voltage-gated Chloride Channel Activity Chloride Channel Activity Protein Binding Phospholipid Scramblase Activity Metal Ion Binding Protein Dimerization Activity	Protein Binding Calcium-dependent Phospholipid Binding Metal Ion Binding
	Biological Process	Activation Of Blood Coagulation Via Clotting Cascade Monoatomic Ion Transport Chloride Transport Lipid Transport Blood Coagulation Plasma Membrane Phospholipid Scrambling Positive Regulation Of Bone Mineralization Bleb Assembly Monoatomic Ion Transmembrane Transport Positive Regulation Of Monoatomic Ion Transmembrane Transport Purinergic Nucleotide Receptor Signaling Pathway Sodium Ion Transmembrane Transport Positive Regulation Of Apoptotic Process Negative Regulation Of Cell Volume Pore Complex Assembly Positive Regulation Of Phagocytosis, Engulfment Calcium Activated Phosphatidylserine Scrambling Calcium Activated Phosphatidylcholine Scrambling Calcium Ion Transmembrane Transport Positive Regulation Of Monocyte Chemotaxis Phosphatidylserine Exposure On Blood Platelet Chloride Transmembrane Transport Positive Regulation Of Potassium Ion Export Across Plasma Membrane Positive Regulation Of Endothelial Cell Apoptotic Process	Cellular Response To Calcium Ion Positive Regulation Of Dendrite Extension
Pathways		Stimuli-sensing channels Neutrophil degranulation Induction of Cell-Cell Fusion	CDC42 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 22138694) Insomnia ( 29520036) Urate levels in obese individuals ( 25811787) Waist circumference adjusted for body mass index ( 28552196)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Arterial stiffness index ( 31235810) Bipolar disorder ( 28115744) Bisphosphonate-associated atypical femoral fracture ( 31006051) Bitter alcoholic beverage consumption ( 31046077) Body mass index ( 25673413) Body size at age 10 ( 32376654) Chronotype ( 30696823) Heart rate ( 23583979) Heart rate response to recovery post exercise ( 29769521) Irritable bowel syndrome ( 29626450) Morning person ( 30696823) Resting heart rate ( 29769521)
Interacting Genes			3 interacting genes: NECAB1 NEIL3 SORBS3
Entrez ID		196527	144402
HPRD ID		18746	16747
Ensembl ID		ENSG00000177119	ENSG00000139117
Uniprot IDs		A0A7P0TBC5 B3KX12 Q4KMQ2	Q86YQ8
PDB IDs
Enriched GO Terms of Interacting Partners?		Myo-inositol Transmembrane Transporter Activity Myo-inositol:proton Symporter Activity Cellular Response To Curcumin Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Caveola Neck Negative Regulation Of Late Endosome To Lysosome Transport Amphisome Peroxidase Inhibitor Activity Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion GTP-dependent Protein Kinase Activity Beta-catenin Destruction Complex Binding Wnt Signalosome Assembly Anterior Visceral Endoderm Cell Migration Negative Regulation Of Cardiac Muscle Cell Myoblast Differentiation Regulation Of Myoblast Differentiation Establishment Of Bipolar Cell Polarity Involved In Cell Morphogenesis Polarized Secretion Of Basement Membrane Proteins In Epithelium Focal Adhesion Disassembly Cell Trailing Edge Dolichyl Pyrophosphate Glc2Man9GlcNAc2 Alpha-1,2-glucosyltransferase Activity UDP-D-xylose:beta-D-glucoside Alpha-1,3-D-xylosyltransferase Activity Myo-inositol Transport Positive Regulation Of Protein Autoubiquitination Response To Curcumin Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Protein Catabolic Process Extracellular Matrix Constituent Secretion Tear Secretion Protein Import Into Nucleus Synaptic Vesicle Growth Cone Cytoplasmic Side Of Mitochondrial Outer Membrane Positive Regulation Of Post-translational Protein Modification Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Import Into Nucleus Positive Regulation Of Dopamine Receptor Signaling Pathway Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Multivesicular Body, Internal Vesicle Regulation Of Postsynapse Organization Regulation Of CAMKK-AMPK Signaling Cascade Regulation Of Branching Morphogenesis Of A Nerve Regulation Of Synaptic Vesicle Transport Embryonic Nail Plate Morphogenesis Maintenance Of Postsynaptic Density Structure UDP-xylosyltransferase Activity Regulation Of Protein Autoubiquitination Positive Regulation Of Synaptic Vesicle Endocytosis Negative Regulation Of Protein Targeting To Mitochondrion Regulation Of Kidney Size	Depurination MCM Complex Binding Positive Regulation Of Potassium Ion Export Across Plasma Membrane Activation Of Blood Coagulation Via Clotting Cascade Calcium Activated Phosphatidylserine Scrambling Calcium Activated Phospholipid Scrambling Calcium Activated Phosphatidylcholine Scrambling Phosphatidylserine Exposure On Blood Platelet Vinculin Binding Cell-substrate Junction Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Bubble DNA Binding Single Strand Break Repair DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity DNA N-glycosylase Activity Hydrolase Activity, Hydrolyzing N-glycosyl Compounds Negative Regulation Of Cell Volume Calcium-activated Cation Channel Activity Regulation Of Potassium Ion Export Across Plasma Membrane Voltage-gated Monoatomic Ion Channel Activity Voltage-gated Chloride Channel Activity Positive Regulation Of Phagocytosis, Engulfment Bleb Assembly Base-excision Repair, AP Site Formation Intracellularly Calcium-gated Chloride Channel Activity Regulation Of Amyloid Precursor Protein Biosynthetic Process Phospholipid Scramblase Activity Pore Complex Assembly Plasma Membrane Phospholipid Scrambling Positive Regulation Of Monocyte Chemotaxis Purinergic Nucleotide Receptor Signaling Pathway Positive Regulation Of Endothelial Cell Apoptotic Process Blastocyst Hatching Positive Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Blood Coagulation DNA Modification Positive Regulation Of Coagulation Regulation Of Monocyte Chemotaxis Positive Regulation Of Potassium Ion Transport
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