ANO6 and SLC2A13

		ANO6	SLC2A13
Description		anoctamin 6	solute carrier family 2 member 13
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Cell Surface Membrane Monoatomic Ion Channel Complex Chloride Channel Complex Specific Granule Membrane Extracellular Exosome Tertiary Granule Membrane	Cytoplasm Lysosome Early Endosome Golgi Apparatus Plasma Membrane Synaptic Vesicle Membrane Apical Plasma Membrane Growth Cone Organelle Membrane Cell Projection Intracellular Membrane-bounded Organelle Cell Body Cell Periphery Astrocyte End-foot
	Molecular Function	Calcium-activated Cation Channel Activity Intracellularly Calcium-gated Chloride Channel Activity Voltage-gated Monoatomic Ion Channel Activity Voltage-gated Chloride Channel Activity Chloride Channel Activity Protein Binding Phospholipid Scramblase Activity Metal Ion Binding Protein Dimerization Activity	Protease Binding Myo-inositol Transmembrane Transporter Activity Myo-inositol:proton Symporter Activity Protein Binding Transmembrane Transporter Activity ATPase Binding
	Biological Process	Activation Of Blood Coagulation Via Clotting Cascade Monoatomic Ion Transport Chloride Transport Lipid Transport Blood Coagulation Plasma Membrane Phospholipid Scrambling Positive Regulation Of Bone Mineralization Bleb Assembly Monoatomic Ion Transmembrane Transport Positive Regulation Of Monoatomic Ion Transmembrane Transport Purinergic Nucleotide Receptor Signaling Pathway Sodium Ion Transmembrane Transport Positive Regulation Of Apoptotic Process Negative Regulation Of Cell Volume Pore Complex Assembly Positive Regulation Of Phagocytosis, Engulfment Calcium Activated Phosphatidylserine Scrambling Calcium Activated Phosphatidylcholine Scrambling Calcium Ion Transmembrane Transport Positive Regulation Of Monocyte Chemotaxis Phosphatidylserine Exposure On Blood Platelet Chloride Transmembrane Transport Positive Regulation Of Potassium Ion Export Across Plasma Membrane Positive Regulation Of Endothelial Cell Apoptotic Process	Myo-inositol Transport Transmembrane Transport Transport Across Blood-brain Barrier Positive Regulation Of Amyloid-beta Formation
Pathways		Stimuli-sensing channels Neutrophil degranulation Induction of Cell-Cell Fusion	Inositol transporters
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 22138694) Insomnia ( 29520036) Urate levels in obese individuals ( 25811787) Waist circumference adjusted for body mass index ( 28552196)	Alzheimer's disease in hypertension ( 31055733) Coronary artery calcification ( 23870195) Crohn's disease ( 28067908) Daytime sleep phenotypes ( 27126917) Disability (impaired activities of daily living) ( 31707593) Inflammatory bowel disease ( 28067908) Insomnia ( 23728906) Parkinson's disease ( 22451204 28011712 32201043) Putamen volume ( 31530798) Sleep quality ( 23728906)
Interacting Genes			4 interacting genes: CYP4F2 FXYD6-FXYD2 PLP2 RIC8A
Entrez ID		196527	114134
HPRD ID		18746	15363
Ensembl ID		ENSG00000177119	ENSG00000151229
Uniprot IDs		A0A7P0TBC5 B3KX12 Q4KMQ2	Q96QE2
PDB IDs
Enriched GO Terms of Interacting Partners?		Myo-inositol Transmembrane Transporter Activity Myo-inositol:proton Symporter Activity Cellular Response To Curcumin Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Caveola Neck Negative Regulation Of Late Endosome To Lysosome Transport Amphisome Peroxidase Inhibitor Activity Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion GTP-dependent Protein Kinase Activity Beta-catenin Destruction Complex Binding Wnt Signalosome Assembly Anterior Visceral Endoderm Cell Migration Negative Regulation Of Cardiac Muscle Cell Myoblast Differentiation Regulation Of Myoblast Differentiation Establishment Of Bipolar Cell Polarity Involved In Cell Morphogenesis Polarized Secretion Of Basement Membrane Proteins In Epithelium Focal Adhesion Disassembly Cell Trailing Edge Dolichyl Pyrophosphate Glc2Man9GlcNAc2 Alpha-1,2-glucosyltransferase Activity UDP-D-xylose:beta-D-glucoside Alpha-1,3-D-xylosyltransferase Activity Myo-inositol Transport Positive Regulation Of Protein Autoubiquitination Response To Curcumin Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Protein Catabolic Process Extracellular Matrix Constituent Secretion Tear Secretion Protein Import Into Nucleus Synaptic Vesicle Growth Cone Cytoplasmic Side Of Mitochondrial Outer Membrane Positive Regulation Of Post-translational Protein Modification Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Import Into Nucleus Positive Regulation Of Dopamine Receptor Signaling Pathway Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Multivesicular Body, Internal Vesicle Regulation Of Postsynapse Organization Regulation Of CAMKK-AMPK Signaling Cascade Regulation Of Branching Morphogenesis Of A Nerve Regulation Of Synaptic Vesicle Transport Embryonic Nail Plate Morphogenesis Maintenance Of Postsynaptic Density Structure UDP-xylosyltransferase Activity Regulation Of Protein Autoubiquitination Positive Regulation Of Synaptic Vesicle Endocytosis Negative Regulation Of Protein Targeting To Mitochondrion Regulation Of Kidney Size	Alpha-tocopherol Omega-hydroxylase Activity Negative Regulation Of Icosanoid Secretion Leukotriene B4 Catabolic Process 20-hydroxy-leukotriene B4 Omega Oxidase Activity Alkane 1-monooxygenase Activity 20-aldehyde-leukotriene B4 20-monooxygenase Activity Leukotriene B4 Metabolic Process Arachidonate Omega-hydroxylase Activity Coagulation Blood Coagulation Hemostasis Leukotriene-B4 20-monooxygenase Activity Pressure Natriuresis Cell-cell Adhesion Involved In Gastrulation Positive Regulation Of Potassium Ion Export Across Plasma Membrane Activation Of Blood Coagulation Via Clotting Cascade Calcium Activated Phosphatidylserine Scrambling Calcium Activated Phospholipid Scrambling Calcium Activated Phosphatidylcholine Scrambling Phosphatidylserine Exposure On Blood Platelet Phylloquinone Catabolic Process Long-chain Fatty Acid Omega-hydroxylase Activity Vitamin K Catabolic Process Vitamin E Metabolic Process Menaquinone Metabolic Process Fatty Acid Omega-oxidation Menaquinone Catabolic Process Negative Regulation Of Cell Volume Chemokine Binding Long-chain Fatty Acid Catabolic Process Negative Regulation Of Fatty Acid Transport Arachidonate Epoxygenase Activity Regulation Of Body Fluid Levels Omega-hydroxylase P450 Pathway Voltage-gated Chloride Channel Activity Bleb Assembly Calcium-activated Cation Channel Activity Voltage-gated Monoatomic Ion Channel Activity Monoatomic Ion Transmembrane Transporter Activity Epoxygenase P450 Pathway Vitamin K Metabolic Process Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen Cell Migration Involved In Gastrulation Regulation Of Potassium Ion Export Across Plasma Membrane Positive Regulation Of Phagocytosis, Engulfment Intracellularly Calcium-gated Chloride Channel Activity Positive Regulation Of Icosanoid Secretion Ketone Catabolic Process Renal Water Homeostasis Phospholipid Scramblase Activity
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