PIANP and DEFB127

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PIANP	DEFB127
Description		PILR alpha associated neural protein	defensin beta 127
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Basolateral Plasma Membrane Presynapse	Extracellular Region
	Molecular Function	Protein Binding Protein Domain Specific Binding	Protein Binding
	Biological Process	Response To Stress Gamma-aminobutyric Acid Signaling Pathway Visual Learning Gene Expression Glutamate Secretion Dentate Gyrus Development Cerebellum Development Social Behavior Homeostasis Of Number Of Cells Regulation Of Immune Response	Defense Response Defense Response To Bacterium Innate Immune Response Defense Response To Gram-negative Bacterium Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Beta defensins Defensins
Drugs
Diseases
GWAS			Coronary artery disease in type 1 diabetes ( 32077919)
Interacting Genes		4 interacting genes: CMTM7 DEFB127 TMBIM6 UBQLN2	14 interacting genes: AQP6 ASZ1 AURKAIP1 BCL2L13 CD79A CPLX4 EBP FAM174A FCER1G LMNA MMGT1 PIANP SLC71A2 TFEC
Entrez ID		196500	140850
HPRD ID		13205	10877
Ensembl ID		ENSG00000139200	ENSG00000088782
Uniprot IDs		Q8IYJ0	Q9H1M4
PDB IDs
Enriched GO Terms of Interacting Partners?		Endoribonuclease Inhibitor Activity Regulation Of Response To Endoplasmic Reticulum Stress Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Negative Regulation Of G Protein-coupled Receptor Internalization B-1a B Cell Differentiation Negative Regulation Of Calcium Ion Transport Into Cytosol Response To Endoplasmic Reticulum Stress Negative Regulation Of Clathrin-dependent Endocytosis B-1 B Cell Differentiation Autophagy Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of IRE1-mediated Unfolded Protein Response IRE1-mediated Unfolded Protein Response Negative Regulation Of Immunoglobulin Production Cellular Response To Unfolded Protein Negative Regulation Of Cellular Response To Hypoxia Regulation Of IRE1-mediated Unfolded Protein Response Negative Regulation Of Transport Negative Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of ERAD Pathway Negative Regulation Of Receptor Internalization Regulation Of Clathrin-dependent Endocytosis Response To L-glutamate Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Cellular Response To Hypoxia Regulation Of Cellular Response To Stress Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Regulation Of ERAD Pathway Negative Regulation Of RNA Splicing Cellular Response To Topologically Incorrect Protein
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