ZNF92 and CCR6

		ZNF92	CCR6
Description		zinc finger protein 92	C-C motif chemokine receptor 6
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Sperm Flagellum Sperm Midpiece Sperm Principal Piece Sperm Plasma Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding	G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding Signaling Receptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription	Dendritic Cell Chemotaxis Leukocyte Migration Involved In Inflammatory Response Chemotaxis Immune Response Humoral Immune Response Cellular Defense Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Isotype Switching To IgA Isotypes Cell Chemotaxis Positive Regulation Of Flagellated Sperm Motility Involved In Capacitation Chemokine-mediated Signaling Pathway Lymphocyte Migration T Cell Migration Thymocyte Migration DN2 Thymocyte Differentiation DN3 Thymocyte Differentiation Regulation Of T Cell Migration Positive Regulation Of Dendritic Cell Chemotaxis
Pathways		Generic Transcription Pathway	Beta defensins Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs
Diseases
GWAS			Albumin-globulin ratio ( 29403010) Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229) Basal cell carcinoma ( 31174203) Crohn's disease ( 28067908 18587394 23850713 21102463 20570966) Graves' disease ( 22922229) Inflammatory bowel disease ( 23128233 27569725 28067908) Keratinocyte cancer (MTAG) ( 31174203) Lung cancer ( 28604730) Primary biliary cholangitis ( 28425483) Response to zileuton treatment in asthma (FEV1 change interaction) ( 26031901) Rheumatoid arthritis ( 30423114 24782177 32723749 24390342 23143596 20453841) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Social autistic-like traits ( 24133439) Triglycerides ( 24886709) Vitiligo ( 27723757 20526339)
Interacting Genes		4 interacting genes: APP CREB1 MEOX2 STAT6	5 interacting genes: CCL20 DEFB1 DEFB103B DEFB4A QSOX1
Entrez ID		168374	1235
HPRD ID		04919	03498
Ensembl ID		ENSG00000146757	ENSG00000112486
Uniprot IDs		C9IZS8 Q03936 V9HVY7	P51684
PDB IDs			6WWZ
Enriched GO Terms of Interacting Partners?		Cell Activation Involved In Immune Response Positive Regulation Of Long-term Synaptic Potentiation Axonogenesis Cellular Response To Metal Ion Isotype Switching Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Somatic Diversification Of Immunoglobulins Involved In Immune Response Cell Projection Morphogenesis Response To Nerve Growth Factor Neuron Projection Morphogenesis Regulation Of Long-term Synaptic Potentiation Cellular Response To Nerve Growth Factor Stimulus Somatic Recombination Of Immunoglobulin Gene Segments Somatic Cell DNA Recombination Somatic Diversification Of Immunoglobulins Response To Metal Ion Chemotaxis Regulation Of T Cell Migration Transcription Coactivator Binding Visual Learning Positive Regulation Of Immune System Process Locomotion Visual Behavior Regulation Of Multicellular Organism Growth Immune Effector Process B Cell Activation Involved In Immune Response Regulation Of Lymphocyte Migration Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Isotype Switching To IgA Isotypes DN3 Thymocyte Differentiation Chemotaxis To Arachidonate DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Transcription By RNA Polymerase II Sequence-specific DNA Binding Associative Learning Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Chemotaxis Acetylcholine Receptor Activator Activity Anatomical Structure Morphogenesis Lipoprotein Particle Developmental Process Leukocyte Activation Positive Regulation Of Protein Import Positive Regulation Of Flagellated Sperm Motility Involved In Capacitation Positive Regulation Of Cardiac Muscle Tissue Development Positive Regulation Of Transforming Growth Factor Beta3 Production	CCR6 Chemokine Receptor Binding Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Antimicrobial Humoral Response Humoral Immune Response Defense Response To Gram-negative Bacterium Locomotion Defense Response To Bacterium Chemotaxis Golgi Lumen Defense Response To Other Organism Defense Response To Gram-positive Bacterium Defense Response To Symbiont Killing Of Cells Of Another Organism Response To Bacterium Chemoattractant Activity Cell Killing Cell Chemotaxis Response To Other Organism Positive Chemotaxis Immune Response Negative Regulation Of Selenocysteine Incorporation Cellular Response To Selenite Ion Saccharopine Dehydrogenase (NADP+, L-lysine-forming) Activity Saccharopine Dehydrogenase Activity Saccharopine Dehydrogenase (NAD+, L-lysine-forming) Activity Saccharopine Dehydrogenase (NAD+, L-glutamate-forming) Activity Response To External Biotic Stimulus Defense Response Phosphatidylinositol-4,5-bisphosphate Binding Positive Regulation Of Flagellated Sperm Motility Involved In Capacitation Regulation Of Response To DNA Integrity Checkpoint Signaling Extracellular Space Cell Migration Flavin-dependent Sulfhydryl Oxidase Activity Thymocyte Migration Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission L-lysine Catabolic Process To Acetyl-CoA Via Saccharopine Nuclear Speck Selenocysteine Insertion Sequence Binding Regulation Of Translation At Postsynapse L-lysine Catabolic Process Negative Regulation Of Translational Elongation Cell Motility Thiol Oxidase Activity Splicing Factor Binding Immune System Process Lysine Catabolic Process Negative Regulation Of Centriole Replication Calcium-mediated Signaling Positive Regulation Of Gene Expression
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