DDX10 and BCO2

		DDX10	BCO2
Description		DEAD-box helicase 10	beta-carotene oxygenase 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm	Mitochondrion Mitochondrial Matrix
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity	Beta-carotene 15,15'-dioxygenase Activity Carotenoid Dioxygenase Activity 9,10 (9', 10')-carotenoid-cleaving Dioxygenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Metal Ion Binding Dioxygenase Activity Beta,beta-carotene-9',10'-cleaving Oxygenase Activity
	Biological Process	RRNA Processing Anterior Head Development	Lipid Metabolic Process Carotenoid Metabolic Process Carotene Metabolic Process Carotene Catabolic Process Xanthophyll Metabolic Process Xanthophyll Catabolic Process Retinoic Acid Metabolic Process Retinal Metabolic Process Regulation Of Mitochondrial Membrane Potential Lutein Catabolic Process Lycopene Catabolic Process Zeaxanthin Catabolic Process Regulation Of Reactive Oxygen Species Metabolic Process
Pathways			Retinoid metabolism and transport
Drugs
Diseases
GWAS		Bipolar disorder ( 34099189) Femur bone mineral density x serum urate levels interaction ( 34046847) Knee osteoarthritis ( 28916551) Systolic blood pressure ( 27841878)	Immune reponse to smallpox (secreted IL-12p40) ( 22610502) Inflammatory biomarkers ( 24182552) Interleukin-18 levels ( 20150558 31584380)
Interacting Genes		4 interacting genes: APP FBXO7 RNF10 SIRPA
Entrez ID		1662	83875
HPRD ID		03138	12522
Ensembl ID		ENSG00000178105	ENSG00000197580
Uniprot IDs		Q13206	B2RCV8 Q9BYV7
PDB IDs		2PL3
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of System Process Lipoprotein Particle Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Protein Import Regulation Of Nitric Oxide Metabolic Process Insulin-like Growth Factor Binary Complex Maintenance Of Protein Location In Nucleus Maintenance Of Protein Localization In Organelle Maintenance Of Protein Location Maintenance Of Protein Location In Cell 6-pyruvoyltetrahydropterin Synthase Activity Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Symbiont-mediated Suppression Of Host Innate Immune Response SCF Ubiquitin Ligase Complex GTPase Regulator Activity Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Carotene Metabolic Process Xanthophyll Catabolic Process Zeaxanthin Catabolic Process Carotenoid Dioxygenase Activity 9,10 (9', 10')-carotenoid-cleaving Dioxygenase Activity Lutein Catabolic Process Beta,beta-carotene-9',10'-cleaving Oxygenase Activity Carotene Catabolic Process Xanthophyll Metabolic Process Lycopene Catabolic Process Cellular Response To Interleukin-12 PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Maintenance Of Location In Cell Maintenance Of Location	Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere DNA-dependent Protein Kinase Activity Cellular Response To Nitrosative Stress Peptidyl-serine Autophosphorylation Positive Regulation Of Telomerase Catalytic Core Complex Assembly Histone H2AXS139 Kinase Activity Pre-B Cell Allelic Exclusion Anterior Head Development Cellular Response To X-ray Positive Regulation Of Vacuole Organization Lipoprotein Metabolic Process Mitotic G2 DNA Damage Checkpoint Signaling Female Gonad Development DNA Double-strand Break Processing Response To X-ray Lipoprotein Catabolic Process Cellular Response To Gamma Radiation DNA Repair Complex Female Meiotic Nuclear Division Oocyte Development Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Telomere Maintenance Via Telomerase Extrinsic Component Of Synaptic Vesicle Membrane Meiotic Telomere Clustering Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Telomere Capping Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator DNA Strand Resection Involved In Replication Fork Processing Replicative Senescence Pexophagy Nucleolus Regulation Of Cellular Response To Heat Reciprocal Meiotic Recombination Negative Regulation Of B Cell Activation Histone MRNA Metabolic Process Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Negative Regulation Of B Cell Proliferation 1-phosphatidylinositol-3-kinase Activity Histone MRNA Catabolic Process Determination Of Adult Lifespan V(D)J Recombination Positive Regulation Of Autophagosome Assembly Negative Regulation Of Telomere Capping Phosphatidylinositol-3-phosphate Biosynthetic Process Telomere Localization Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Response To Nitrosative Stress Protein Localization To Site Of Double-strand Break
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