BCO2

Description		beta-carotene oxygenase 2
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix
	Molecular Function	Beta-carotene 15,15'-dioxygenase Activity Carotenoid Dioxygenase Activity 9,10 (9', 10')-carotenoid-cleaving Dioxygenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Metal Ion Binding Dioxygenase Activity Beta,beta-carotene-9',10'-cleaving Oxygenase Activity
	Biological Process	Lipid Metabolic Process Carotenoid Metabolic Process Carotene Metabolic Process Carotene Catabolic Process Xanthophyll Metabolic Process Xanthophyll Catabolic Process Retinoic Acid Metabolic Process Retinal Metabolic Process Regulation Of Mitochondrial Membrane Potential Lutein Catabolic Process Lycopene Catabolic Process Zeaxanthin Catabolic Process Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Retinoid metabolism and transport
Drugs
Diseases
GWAS		Immune reponse to smallpox (secreted IL-12p40) ( 22610502) Inflammatory biomarkers ( 24182552) Interleukin-18 levels ( 20150558 31584380)
Novel Interacting Genes		2 novel interacting genes: ATM DDX10
Interacting Genes
Entrez ID		83875
HPRD ID		12522
Ensembl ID		ENSG00000197580
Uniprot IDs		B2RCV8 Q9BYV7
PDB IDs
Enriched GO Terms of Interacting Partners?		Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere DNA-dependent Protein Kinase Activity Cellular Response To Nitrosative Stress Peptidyl-serine Autophosphorylation Positive Regulation Of Telomerase Catalytic Core Complex Assembly Histone H2AXS139 Kinase Activity Pre-B Cell Allelic Exclusion Anterior Head Development Cellular Response To X-ray Positive Regulation Of Vacuole Organization Lipoprotein Metabolic Process Mitotic G2 DNA Damage Checkpoint Signaling Female Gonad Development DNA Double-strand Break Processing Response To X-ray Lipoprotein Catabolic Process Cellular Response To Gamma Radiation DNA Repair Complex Female Meiotic Nuclear Division Oocyte Development Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Telomere Maintenance Via Telomerase Extrinsic Component Of Synaptic Vesicle Membrane Meiotic Telomere Clustering Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Telomere Capping Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator DNA Strand Resection Involved In Replication Fork Processing Replicative Senescence Pexophagy Nucleolus Regulation Of Cellular Response To Heat Reciprocal Meiotic Recombination Negative Regulation Of B Cell Activation Histone MRNA Metabolic Process Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Negative Regulation Of B Cell Proliferation 1-phosphatidylinositol-3-kinase Activity Histone MRNA Catabolic Process Determination Of Adult Lifespan V(D)J Recombination Positive Regulation Of Autophagosome Assembly Negative Regulation Of Telomere Capping Phosphatidylinositol-3-phosphate Biosynthetic Process Telomere Localization Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Response To Nitrosative Stress Protein Localization To Site Of Double-strand Break
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