XIRP1 and TRANK1

		XIRP1	TRANK1
Description		xin actin binding repeat containing 1	tetratricopeptide repeat and ankyrin repeat containing 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Stress Fiber Adherens Junction Focal Adhesion Cell Junction Desmosome Anchoring Junction
	Molecular Function	RNA Binding Actin Binding Protein Binding Actin Filament Binding
	Biological Process	Actin Filament Organization Intracellular Protein Localization Myoblast Differentiation Involved In Skeletal Muscle Regeneration Satellite Cell Activation Involved In Skeletal Muscle Regeneration Actin Cytoskeleton Organization Negative Regulation Of Protein Binding
Pathways
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Cognitive decline rate in late mild cognitive impairment ( 26252872) Daytime sleep phenotypes ( 27126917) Social communication problems ( 24564958)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Apolipoprotein A1 levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 22182935 34002096 24618891 33263727 27329760 28072414 28115744 31043756) Bipolar disorder with mood-incongruent psychosis ( 23092984) Bipolar I disorder ( 31043756) Chronotype ( 30696823) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Iris color (L* coordinate) ( 29109912) Kleine-Levin syndrome ( 33737391) Mean platelet volume ( 32888494) Morning person ( 30696823) Platelet distribution width ( 27863252) Pulse pressure ( 30224653) Schizophrenia ( 29483656 25056061 28991256 30285260) Schizophrenia or bipolar disorder ( 24280982) Subjective response to lithium treatment ( 26503763) Triglycerides ( 30275531)
Interacting Genes		9 interacting genes: ACTA1 ENAH EVL FLNC NEB NEBL RNF10 SH3RF1 VASP
Entrez ID		165904	9881
HPRD ID		16727	19247
Ensembl ID		ENSG00000168334	ENSG00000168016
Uniprot IDs		Q702N8	A0A2R8YEM9 O15050
PDB IDs
Enriched GO Terms of Interacting Partners?		Actin Filament Organization Actin Binding Profilin Binding Lamellipodium Supramolecular Fiber Organization Cardiac Muscle Thin Filament Assembly Actin Polymerization Or Depolymerization Filopodium Stress Fiber SH3 Domain Binding Cytoskeleton Z Disc Focal Adhesion Regulation Of Actin Filament Length Actin Filament Binding Neuron Projection Guidance Axon Guidance Structural Constituent Of Muscle Regulation Of Cellular Component Size Positive Regulation Of Actin Filament Polymerization Sarcomere Actin Cytoskeleton Protein Homotetramerization Cytoskeletal Protein Binding Protein Autoubiquitination Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Protein Polymerization Regulation Of Actin Filament-based Process Protein Tetramerization Muscle Cell Development Cytoplasm Regulation Of Actin Filament Polymerization Neuron Projection Development Somatic Muscle Development Mesenchyme Migration Regulation Of Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Skeletal Muscle Thin Filament Assembly Cell Projection Negative Regulation Of Ruffle Assembly Actin Polymerization-dependent Cell Motility Positive Regulation Of Supramolecular Fiber Organization Negative Regulation Of Schwann Cell Proliferation Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Positive Regulation Of Cytoskeleton Organization Striated Muscle Thin Filament Protein Homooligomerization Ribosome-associated Ubiquitin-dependent Protein Catabolic Process	LRR Domain Binding Myoblast Differentiation Involved In Skeletal Muscle Regeneration Satellite Cell Activation Involved In Skeletal Muscle Regeneration Skeletal Muscle Satellite Cell Activation
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