SDE2 and DNAH14

		SDE2	DNAH14
Description		spliceosome associated SDE2	dynein axonemal heavy chain 14
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Golgi Apparatus Cytosol Plasma Membrane Nuclear Speck	Cytoplasm Cytoskeleton Microtubule Cilium Dynein Complex Cell Projection 9+2 Motile Cilium
	Molecular Function	DNA Binding Damaged DNA Binding RNA Binding Protein Binding SnoRNA Binding	Nucleotide Binding ATP Binding Minus-end-directed Microtubule Motor Activity Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding
	Biological Process	Endonucleolytic Cleavage Of Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) DNA Replication MRNA Processing RNA Splicing Protein Processing Protein Ubiquitination Mitotic G1 DNA Damage Checkpoint Signaling Cellular Response To UV Ribosome Biogenesis MRNA Cis Splicing, Via Spliceosome Cell Division	Microtubule-based Movement Cilium Movement Involved In Cell Motility
Pathways		mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS			Adult body size ( 32376654) Copper levels ( 26025379) Delirium ( 29631748) Feeling nervous ( 29500382) Femur bone mineral density x serum urate levels interaction ( 34046847) Gut microbiota relative abundance (Bifidobacterium) ( 33208821) Heel bone mineral density x serum urate levels interaction ( 34046847) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377)
Interacting Genes		2 interacting genes: OGT PCNA	2 interacting genes: APP FBXO7
Entrez ID		163859	127602
HPRD ID		08180	19478
Ensembl ID		ENSG00000143751	ENSG00000185842
Uniprot IDs		Q6IQ49	A0A804HLD3 M9MMK7 Q0VDD8
PDB IDs		6QDV 7N99 8C6J 8RO2 9FMD
Enriched GO Terms of Interacting Partners?		PCNA Complex Replisome Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Deoxyribonuclease Activity PCNA-p21 Complex DNA Polymerase Processivity Factor Activity Rhythmic Process Mitotic Telomere Maintenance Via Semi-conservative Replication Dinucleotide Insertion Or Deletion Binding Leading Strand Elongation Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Protein O-acetylglucosaminyltransferase Activity MutLalpha Complex Binding Telomere Maintenance Via Semi-conservative Replication Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Positive Regulation Of DNA-directed DNA Polymerase Activity Regulation Of Transcription By Glucose Estrous Cycle NSL Complex Nuclear Lamina DNA Strand Elongation Involved In DNA Replication Base-excision Repair, Gap-filling Minus-end-directed Microtubule Motor Activity DNA Strand Elongation Nuclear Replication Fork Response To L-glutamate Ovulation Cycle Acetylglucosaminyltransferase Activity Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Response To Hormone DNA Polymerase Binding Sin3-type Complex Translesion Synthesis Histone Acetyltransferase Complex Negative Regulation Of Stem Cell Population Maintenance Replication Fork Liver Regeneration Mismatch Repair Histone Acetyltransferase Binding Regulation Of Receptor Localization To Synapse Regulation Of Protein Localization To Synapse Dynein Light Intermediate Chain Binding Regulation Of Necroptotic Process 9+2 Motile Cilium Replication Fork Processing	Amyloid-beta Complex Dendritic Shaft Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Cell Cycle G1/S Phase Transition Glial Cytoplasmic Inclusion Classical Lewy Body Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Lewy Body Corona Lewy Neurite Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Regulation Of Mitotic Cell Cycle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Surfactant Secretion Lewy Body Core Positive Regulation Of Mesoderm Development Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Osmolarity-sensing Monoatomic Cation Channel Activity Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Hemopoiesis Regulation Of Toll Signaling Pathway
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