DNAAF4 and WDR72

		DNAAF4	WDR72
Description		dynein axonemal assembly factor 4	WD repeat domain 72
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Cytosol Plasma Membrane Cell Projection Neuron Projection Dynein Axonemal Particle	Cytoplasm Cytoplasmic Vesicle
	Molecular Function	Protein Binding Nuclear Estrogen Receptor Binding
	Biological Process	Neuron Migration Cilium Movement Epithelial Cilium Movement Involved In Extracellular Fluid Movement Determination Of Left/right Symmetry Nervous System Development Heart Development Learning Or Memory Regulation Of Intracellular Estrogen Receptor Signaling Pathway Outer Dynein Arm Assembly Inner Dynein Arm Assembly Establishment Of Localization In Cell Regulation Of Proteasomal Protein Catabolic Process	Biomineral Tissue Development Protein Localization To Plasma Membrane
Pathways
Drugs
Diseases
GWAS			Asthma ( 27611488) Blood urea nitrogen levels ( 31152163 29403010) C-reactive protein levels ( 33339817) Chloride levels ( 29403010) Chronic kidney disease ( 20383146 31152163 29124443) Chronotype ( 30696823) Cognitive function ( 22126837) Coronary artery disease in type 1 diabetes ( 32077919) Corpus callosum mid-anterior volume ( 31530798) Creatinine levels ( 29124443 29403010) Estimated glomerular filtration rate ( 29124443 31152163 31015462 30604766) Estimated glomerular filtration rate (creatinine, CKDi25) ( 33137338) Estimated glomerular filtration rate in diabetes ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glomerular filtration rate ( 27588450 29403010) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Height ( 31562340) Hematological and biochemical traits ( 20139978) Hyperuricemia ( 29124443) Kidney stones ( 31729369) Lead levels ( 26025379) Longevity ( 20834067) Low urine pH ( 30476138) Macular thickness ( 30535121) Metabolite levels ( 23823483) Mitochondrial heteroplasmy measurement ( 33731350) Potassium levels ( 29403010) Proliferative diabetic retinopathy ( 31482010) Renal function-related traits (BUN) ( 22797727) Renal function-related traits (eGRFcrea) ( 22797727) Renal function-related traits (sCR) ( 22797727) Serum uric acid levels ( 29124443) Smoking initiation (ever regular vs never regular) ( 30679032) Sodium levels ( 29403010) Type 2 diabetes ( 30297969) Urine pH measurement ( 30476138) Waist circumference ( 34074324)
Interacting Genes		10 interacting genes: BANF2 CRACR2B EXOC5 HSPA1A KDM1A KRT13 MCC SPDL1 STUB1 TRIM23	1 interacting genes: FOXP1
Entrez ID		161582	256764
HPRD ID		10568	10987
Ensembl ID		ENSG00000256061	ENSG00000166415
Uniprot IDs		A0A0S2Z5Z4 Q8WXU2	A0A087WTC3 Q3MJ13
PDB IDs
Enriched GO Terms of Interacting Partners?			Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Interleukin-21 Production Monocyte Activation Regulation Of Defense Response To Bacterium Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Negative Regulation Of B Cell Apoptotic Process Osteoclast Development Negative Regulation Of Androgen Receptor Signaling Pathway Striatum Development Positive Regulation Of B Cell Receptor Signaling Pathway Endothelial Cell Activation Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Regulation Of Monocyte Differentiation T Follicular Helper Cell Differentiation Core Promoter Sequence-specific DNA Binding Regulation Of B Cell Apoptotic Process Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Macrophage Colony-stimulating Factor Production Regulation Of Endothelial Tube Morphogenesis Dynein Axonemal Particle Outer Dynein Arm Assembly Inner Dynein Arm Assembly Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of Cardiac Muscle Tissue Growth Nuclear Androgen Receptor Binding Positive Regulation Of Antigen Receptor-mediated Signaling Pathway T-helper Cell Differentiation Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Muscle Hypertrophy Response To Testosterone Negative Regulation Of Lymphocyte Apoptotic Process Negative Regulation Of Organ Growth Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of Cardiac Muscle Hypertrophy Axonemal Dynein Complex Assembly Regulation Of Intracellular Estrogen Receptor Signaling Pathway Nuclear Estrogen Receptor Binding Negative Regulation Of Striated Muscle Cell Differentiation T Cell Differentiation Involved In Immune Response Epithelial Cilium Movement Involved In Extracellular Fluid Movement Osteoclast Differentiation CD4-positive, Alpha-beta T Cell Differentiation Extracellular Transport T Cell Activation Involved In Immune Response Regulation Of Heart Growth Macrophage Activation Alpha-beta T Cell Differentiation Forebrain Development Regulation Of Lymphocyte Apoptotic Process
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