DARS1 and MIR429

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		DARS1	MIR429
Description		aspartyl-tRNA synthetase 1	microRNA 429
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane Aminoacyl-tRNA Synthetase Multienzyme Complex Synapse Extracellular Exosome
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Binding Aminoacylase Activity Aminoacyl-tRNA Ligase Activity Aspartate-tRNA Ligase Activity Protein Binding ATP Binding Ligase Activity	MRNA 3'-UTR Binding MRNA Base-pairing Post-transcriptional Repressor Activity
	Biological Process	Translation TRNA Aminoacylation For Protein Translation Aspartyl-tRNA Aminoacylation Protein-containing Complex Assembly	MiRNA-mediated Post-transcriptional Gene Silencing
Pathways		Selenoamino acid metabolism Cytosolic tRNA aminoacylation Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs		Aspartic acid
Diseases
GWAS
Interacting Genes		80 interacting genes: AIMP2 CEBPA DSCR9 EEF1A1 ERCC6 ESR1 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I PIK3R3 SUMO2	75 interacting genes: AIMP2 APOBEC3B AQR C1QBP CDC5L DARS1 DDX1 DDX21 DDX23 DDX3X DHX36 DHX37 EIF2AK2 EPRS1 FUS G3BP2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LIN28A LIN28B LRPPRC MARS1 MATR3 MYEF2 NOL6 NONO NUDT21 PDCD11 PTBP1 PTBP3 PUF60 PURA RARS1 RBFOX2 RBM14 RBM4 RTCA RTCB SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 STRBP SUGP2 SYNCRIP TAF15 TRA2A TRA2B U2SURP UPF1 UTP20 XRN1 YBX1 YBX2 YBX3 ZNF346
Entrez ID		1615	554210
HPRD ID		04361
Ensembl ID		ENSG00000115866	ENSG00000198976
Uniprot IDs		A0A140VJW5 P14868
PDB IDs		4J15 5Y6L 6IY6
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RISC Complex Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Extracellular Vesicle Negative Regulation Of Translation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Regulation Of Metabolic Process Negative Regulation Of Cell Migration Negative Regulation Of Cytokine Production Negative Regulation Of Cell Motility Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Locomotion Regulation Of Angiogenesis Positive Regulation Of MRNA Metabolic Process Regulation Of Vasculature Development Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Translation Regulation Of MRNA Stability Negative Regulation Of Multicellular Organismal Process Regulation Of RNA Stability Negative Regulation Of Developmental Process Extracellular Space Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cell Migration Negative Regulation Of Protein Metabolic Process Regulation Of Endothelial Cell Migration Regulation Of Cell Motility Negative Regulation Of Signal Transduction Regulation Of Locomotion Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Blood Vessel Endothelial Cell Migration	RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process RNA Splicing MRNA Processing Nucleic Acid Metabolic Process MRNA Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Binding MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nucleus Regulation Of MRNA Metabolic Process Spliceosomal Complex Regulation Of RNA Splicing Macromolecule Metabolic Process Catalytic Step 2 Spliceosome Nucleoplasm Post-transcriptional Regulation Of Gene Expression Ribonucleoprotein Complex Negative Regulation Of MRNA Metabolic Process Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Translation MiRNA Binding Cytoplasmic Stress Granule Negative Regulation Of RNA Catabolic Process MRNA 3'-UTR Binding Negative Regulation Of Translation Regulation Of Gene Expression Negative Regulation Of MRNA Catabolic Process RNA Stabilization Aminoacyl-tRNA Synthetase Multienzyme Complex Regulation Of Macromolecule Biosynthetic Process Nucleolus MRNA Stabilization Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Cytoplasmic Translation Regulation Of RNA Stability CRD-mediated MRNA Stabilization Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA 5'-UTR Binding Regulation Of MRNA Stability Positive Regulation Of Gene Expression RNA Helicase Activity RNA Transport Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process
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