JAKMIP1 and HTRA3

		JAKMIP1	HTRA3
Description		janus kinase and microtubule interacting protein 1	HtrA serine peptidase 3
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Microtubule Membrane Ribonucleoprotein Complex	Extracellular Region
	Molecular Function	RNA Binding Protein Binding Microtubule Binding Kinase Binding GABA Receptor Binding	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Identical Protein Binding
	Biological Process	Protein Transport Cognition	Proteolysis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Coronary artery disease in type 1 diabetes ( 29695241) Response to angiotensin II receptor blocker therapy ( 22566498) Response to zileuton treatment in asthma (FEV1 change interaction) ( 26031901) Tau burden ( 33426524)	Response to cognitive-behavioural therapy in major depressive disorder ( 31123309)
Interacting Genes		21 interacting genes: ARK2N BLK CBX8 CHRM3 DDX6 DSCR9 ENKD1 FXR1 GABBR1 IL16 JAK1 MCRS1 MRPL11 PSMB1 SCNM1 TSGA10IP TYK2 USP2 YES1 YWHAG ZNHIT2	1 interacting genes: XIAP
Entrez ID		152789	94031
HPRD ID		11292	08821
Ensembl ID		ENSG00000152969	ENSG00000170801
Uniprot IDs		B3KWB6 Q96N16	P83110
PDB IDs			2P3W 4RI0
Enriched GO Terms of Interacting Partners?		Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Growth Hormone Receptor Binding Interleukin-10-mediated Signaling Pathway Type III Interferon-mediated Signaling Pathway Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Type II Interferon-mediated Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT	Positive Regulation Of Protein Linear Polyubiquitination Regulation Of Apoptosis Involved In Tissue Homeostasis Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Protein Linear Polyubiquitination Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Protein Polyubiquitination Copper Ion Homeostasis Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process GABA Receptor Binding Execution Phase Of Apoptosis P38MAPK Cascade Protein Serine/threonine Kinase Binding Regulation Of Protein Polyubiquitination Cysteine-type Endopeptidase Inhibitor Activity Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
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