NFAM1 and CHADL

		NFAM1	CHADL
Description		NFAT activating protein with ITAM motif 1	chondroadherin like
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Azurophil Granule Membrane Membrane Raft	Extracellular Region Extracellular Matrix
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding	Collagen Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Signaling Receptor Activity Collagen Fibril Binding
	Biological Process	Positive Regulation Of Cytokine Production Inflammatory Response Signal Transduction Cell Surface Receptor Signaling Pathway B Cell Differentiation Calcineurin-NFAT Signaling Cascade Intracellular Signal Transduction Regulation Of B Cell Differentiation B Cell Receptor Signaling Pathway Positive Regulation Of B Cell Receptor Signaling Pathway	Negative Regulation Of Chondrocyte Differentiation Negative Regulation Of Collagen Fibril Organization
Pathways		Neutrophil degranulation
Drugs
Diseases
GWAS		Chronotype ( 30696823) Machado-Joseph disease (age at onset) ( 32205469) Refractive error ( 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Caffeine consumption from coffee or tea ( 33287642) Crohn's disease ( 26192919) Depression ( 29700475) Feeling worry ( 29500382) Inflammatory bowel disease ( 26192919) Lamb consumption ( 32066663) Neuroticism ( 27918536 29255261) Osteoarthritis (hip) ( 30374069) Osteoarthritis (with total hip replacement) ( 28319091) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)
Interacting Genes		6 interacting genes: BCL11A CFTR MAL2 SYK TCF4 ZAP70
Entrez ID		150372	150356
HPRD ID		16380	19495
Ensembl ID		ENSG00000235568	ENSG00000100399
Uniprot IDs		Q8NET5	Q6NUI6
PDB IDs
Enriched GO Terms of Interacting Partners?		Beta Selection Positive Regulation Of Developmental Process Regulation Of Developmental Process T Cell Selection Positive Regulation Of Alpha-beta T Cell Proliferation T Cell Receptor Complex Regulation Of Multicellular Organismal Development Regulation Of Cell Differentiation Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of Alpha-beta T Cell Differentiation Phosphotyrosine Residue Binding Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of Cell Differentiation Leukocyte Cell-cell Adhesion Peptidyl-tyrosine Phosphorylation Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Interleukin-15 Receptor Binding Positive Regulation Of Interleukin-3 Production Positive Regulation Of Alpha-beta T Cell Activation Negative Regulation Of Branching Morphogenesis Of A Nerve Negative Regulation Of Neuron Remodeling Positive Regulation Of Exocytosis Positive Regulation Of Cell Development Regulation Of Calcium-mediated Signaling Positive Regulation Of Anion Channel Activity Positive Regulation Of T Cell Proliferation T Cell Aggregation Transcription Regulatory Region Nucleic Acid Binding Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of T Cell Differentiation Regulation Of Alpha-beta T Cell Activation Serotonin Secretion By Platelet Protein Tyrosine Kinase Activity Beta-catenin-TCF7L2 Complex Negative Regulation Of Protein Homooligomerization Negative Regulation Of Neuron Maturation Collagen Fibril Binding Negative Regulation Of Collagen Fibril Organization Positive Regulation Of Enamel Mineralization T Cell Differentiation Serotonin Secretion Positive Regulation Of Lymphocyte Proliferation Antigen Receptor-mediated Signaling Pathway Cellular Response To Molecule Of Fungal Origin Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Mononuclear Cell Proliferation B Cell Receptor Complex TFIIB-class Transcription Factor Binding	Egg Activation Male Pronucleus Assembly Perinuclear Theca
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