SLC30A7 and DPH5

		SLC30A7	DPH5
Description		solute carrier family 30 member 7	diphthamide biosynthesis 5
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Mitochondrion Golgi Apparatus Membrane Sarcoplasmic Reticulum Cytoplasmic Vesicle Vesicle Sarcoplasmic Reticulum Membrane Perinuclear Region Of Cytoplasm Golgi Cis Cisterna Membrane	Cytosol
	Molecular Function	Zinc Ion Transmembrane Transporter Activity Monoatomic Cation Transmembrane Transporter Activity Identical Protein Binding	Methyltransferase Activity Transferase Activity Diphthine Methyl Ester Synthase Activity
	Biological Process	Monoatomic Ion Transport Monoatomic Cation Transport Zinc Ion Transport Intracellular Zinc Ion Homeostasis Transmembrane Transport Zinc Ion Transmembrane Transport Zinc Ion Import Into Golgi Lumen	Protein Histidyl Modification To Diphthamide Methylation
Pathways			Synthesis of diphthamide-EEF2
Drugs			S-adenosyl-L-homocysteine
Diseases
GWAS		Multiple sclerosis ( 21833088 31604244)	Irritable bowel syndrome ( 29673008) QT interval (drug interaction) ( 23459443)
Interacting Genes
Entrez ID		148867	51611
HPRD ID		15369	13037
Ensembl ID		ENSG00000162695	ENSG00000117543
Uniprot IDs		Q8NEW0	B3KWP1 Q9H2P9
PDB IDs		8J7T 8J7U 8J7V 8J7W 8J7X 8J7Y 8J80
Enriched GO Terms of Interacting Partners?		Skeletal Muscle Satellite Cell Commitment Diphthine Methyl Ester Synthase Activity Skeletal Muscle Satellite Cell Differentiation Protein Histidyl Modification To Diphthamide Spinal Cord Association Neuron Differentiation Dorsal/ventral Neural Tube Patterning Positive Regulation Of Myoblast Proliferation Skeletal Muscle Tissue Regeneration Regulation Of Myoblast Proliferation Regulation Of Chromatin Organization Cell Differentiation In Spinal Cord Neuron Fate Commitment Regulation Of Cell Fate Commitment Embryonic Skeletal System Development Tissue Regeneration Skeletal Muscle Tissue Development Dorsal/ventral Pattern Formation Skeletal Muscle Cell Differentiation	Sperm Mitochondrion Organization Golgi Cis Cisterna Membrane Zinc Ion Import Into Golgi Lumen Spermatid Nucleus Differentiation Zinc Ion Import Into Organelle Monoatomic Cation Transmembrane Transporter Activity Acrosome Assembly Zinc Ion Transport Zinc Ion Transmembrane Transporter Activity Zinc Ion Transmembrane Transport Intracellular Zinc Ion Homeostasis Cytoplasmic Vesicle Sarcoplasmic Reticulum Membrane
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