DNAH2 and PIK3R6

		DNAH2	PIK3R6
Description		dynein axonemal heavy chain 2	phosphoinositide-3-kinase regulatory subunit 6
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Axonemal Dynein Complex Microtubule Cilium Axoneme Dynein Complex Motile Cilium Sperm Flagellum Inner Dynein Arm Cell Projection 9+2 Motile Cilium	Cytoplasm Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex Phosphatidylinositol 3-kinase Complex, Class IA Phosphatidylinositol 3-kinase Complex, Class IB Membrane
	Molecular Function	Nucleotide Binding Microtubule Motor Activity ATP Binding Minus-end-directed Microtubule Motor Activity Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding	Protein Binding 1-phosphatidylinositol-4,5-bisphosphate 3-kinase Activity 1-phosphatidylinositol-3-kinase Regulator Activity
	Biological Process	Microtubule-based Movement Inner Dynein Arm Assembly Cilium-dependent Cell Motility Cilium Movement Involved In Cell Motility	Angiogenesis Immune Response G Protein-coupled Receptor Signaling Pathway Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of MAP Kinase Activity Positive Regulation Of T Cell Differentiation Positive Regulation Of Angiogenesis
Pathways			GPVI-mediated activation cascade PIP3 activates AKT signaling Synthesis of PIPs at the plasma membrane Constitutive Signaling by Aberrant PI3K in Cancer CD28 dependent PI3K/Akt signaling G beta:gamma signalling through PI3Kgamma PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Co-stimulation by ICOS
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 34315874) Bitter alcoholic beverage consumption ( 31046077) Brain morphology (MOSTest) ( 32665545) Height ( 31562340) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Mean reticulocyte volume ( 32888494) Platelet count ( 32888494) Plateletcrit ( 27863252) Red blood cell count ( 32888494) Uterine fibroids ( 30194396) White blood cell count ( 27863252 32888494)
Interacting Genes		1 interacting genes: LINC01554	1 interacting genes: PIK3CG
Entrez ID		146754	146850
HPRD ID		17214	12682
Ensembl ID		ENSG00000183914	ENSG00000276231
Uniprot IDs		Q9P225	B3KRK9 Q5UE93
PDB IDs		8J07
Enriched GO Terms of Interacting Partners?			Hepatocyte Apoptotic Process 1-phosphatidylinositol-3-kinase Activity Natural Killer Cell Chemotaxis Regulation Of Fibroblast Apoptotic Process Negative Regulation Of Cardiac Muscle Contraction Secretory Granule Localization Phosphatidylinositol 3-kinase Complex, Class IB Dendritic Cell Migration Negative Regulation Of Blood Circulation Negative Regulation Of Striated Muscle Contraction Positive Regulation Of Rac Protein Signal Transduction Respiratory Burst Involved In Defense Response Phosphatidylinositol-3-phosphate Biosynthetic Process Dendritic Cell Chemotaxis Phosphatidylinositol-mediated Signaling T Cell Chemotaxis Negative Regulation Of Muscle Contraction Phosphatidylinositol 3-kinase Complex Negative Regulation Of Triglyceride Catabolic Process Respiratory Burst 1-phosphatidylinositol-4-phosphate 3-kinase Activity Positive Regulation Of Acute Inflammatory Response Negative Regulation Of Triglyceride Metabolic Process Mast Cell Degranulation Negative Regulation Of Fibroblast Apoptotic Process Negative Regulation Of Heart Contraction Sphingosine-1-phosphate Receptor Signaling Pathway Phosphatidylinositol 3-kinase Complex, Class IA Lymphocyte Chemotaxis 1-phosphatidylinositol-4,5-bisphosphate 3-kinase Activity Sphingolipid Mediated Signaling Pathway Negative Regulation Of Lipid Catabolic Process Neutrophil Extravasation Cellular Extravasation Inner Dynein Arm Minus-end-directed Microtubule Motor Activity Inner Dynein Arm Assembly Axonemal Dynein Complex Dynein Light Intermediate Chain Binding Ephrin Receptor Binding Positive Regulation Of MAP Kinase Activity Regulation Of Rac Protein Signal Transduction Cell Motility T Cell Migration 9+2 Motile Cilium Dynein Intermediate Chain Binding Axonemal Dynein Complex Assembly Dynein Complex Leukocyte Degranulation Regulation Of Triglyceride Metabolic Process
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