HAPLN3 and CRTC3

		HAPLN3	CRTC3
Description		hyaluronan and proteoglycan link protein 3	CREB regulated transcription coactivator 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Synapse Perineuronal Net	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Hyaluronic Acid Binding	Transcription Coactivator Activity Protein Binding CAMP Response Element Binding Protein Binding
	Biological Process	Skeletal System Development Cell Adhesion Central Nervous System Development	Lipid Catabolic Process Macrophage Activation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Lipid Catabolic Process Protein Homotetramerization Cellular Response To CAMP Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Energy Homeostasis
Pathways			Transcriptional activation of mitochondrial biogenesis Heme signaling Expression of BMAL (ARNTL), CLOCK, and NPAS2
Drugs		Hyaluronic acid
Diseases
GWAS		Appendicular lean mass ( 33097823) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Lung cancer in ever smokers ( 28604730) Multiple keratinocyte cancers ( 28081215) Waist circumference adjusted for body mass index ( 34021172)	Apolipoprotein B levels ( 32203549) Chromium levels ( 26025379) Chronic postoperative pain ( 31903573) Colorectal cancer ( 29228715) Daytime sleep phenotypes ( 27126917) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Gastroesophageal reflux disease ( 27485664) Heel bone mineral density ( 28869591) Inflammatory bowel disease ( 23128233 28067908) Information processing speed ( 21130836) Male-pattern baldness ( 28196072) Offspring birth weight ( 31043758) Response to exercise (triglyceride level interaction) ( 26491034) Ulcerative colitis ( 28067908)
Interacting Genes			5 interacting genes: CA13 KLHL12 SIK2 YAP1 YWHAG
Entrez ID		145864	64784
HPRD ID		13629	13384
Ensembl ID		ENSG00000140511	ENSG00000140577
Uniprot IDs		A8K7T8 H3BTH8 Q96S86	Q6UUV7
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway CAMP Response Element Binding Protein Binding Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Lipid Catabolic Process Protein Homotetramerization Regulation Of Lipid Catabolic Process Macrophage Activation Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Cellular Response To CAMP Energy Homeostasis Response To CAMP Protein Tetramerization Negative Regulation Of Lipid Metabolic Process Myeloid Leukocyte Activation Response To Purine-containing Compound Regulation Of G Protein-coupled Receptor Signaling Pathway
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