SMCR8 and DRC3

		SMCR8	DRC3
Description		SMCR8-C9orf72 complex subunit	dynein regulatory complex subunit 3
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Guanyl-nucleotide Exchange Factor Complex Cell Projection Synapse Presynapse Postsynapse Atg1/ULK1 Kinase Complex	Cytoplasm Cytoskeleton Cilium Axoneme Motile Cilium Sperm Flagellum Cell Projection
	Molecular Function	Protein Kinase Inhibitor Activity Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Protein Kinase Binding	Protein Binding
	Biological Process	Autophagy Regulation Of Autophagy Negative Regulation Of Gene Expression Negative Regulation Of Macroautophagy Positive Regulation Of TOR Signaling Negative Regulation Of Exocytosis Negative Regulation Of Immune Response Positive Regulation Of Autophagosome Maturation Negative Regulation Of Autophagosome Assembly Regulation Of TORC1 Signaling
Pathways
Drugs
Diseases
GWAS		Change in neurofilament light levels ( 31295725) Diastolic blood pressure ( 30578418) Systolic blood pressure ( 30578418)
Interacting Genes		4 interacting genes: ATG13 FEM1B TBK1 ULK1	2 interacting genes: MFHAS1 ZNF250
Entrez ID		140775	83450
HPRD ID		18075	13181
Ensembl ID		ENSG00000176994	ENSG00000171962
Uniprot IDs		Q8TEV9	B3KSC6 Q9H069
PDB IDs		6LT0 6V4U 7EL6 7MGE 7O2W	8J07
Enriched GO Terms of Interacting Partners?		Atg1/ULK1 Kinase Complex Phagophore Assembly Site Membrane Positive Regulation Of Autophagy Macroautophagy Microautophagy Nucleophagy Piecemeal Microautophagy Of The Nucleus Phagophore Assembly Site Peptidyl-serine Phosphorylation Autophagy Mitophagy Regulation Of Autophagy Autophagy Of Mitochondrion Autophagosome Autophagosome Assembly Positive Regulation Of Macroautophagy Autophagosome Organization Positive Regulation Of Catabolic Process Omegasome Membrane Epithelial Cell Maturation Involved In Prostate Gland Development Dendritic Cell Proliferation Intracellular Protein Localization Vacuole Organization Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Macroautophagy Catabolic Process Response To Mitochondrial Depolarisation Positive Regulation Of Xenophagy Positive Regulation Of TORC2 Signaling Cellular Response To Nutrient Levels Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway T Follicular Helper Cell Differentiation Negative Regulation Of Collateral Sprouting Branching Involved In Prostate Gland Morphogenesis Regulation Of TORC2 Signaling
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