CRABP1 and CHRNA5

		CRABP1	CHRNA5
Description		cellular retinoic acid binding protein 1	cholinergic receptor nicotinic alpha 5 subunit
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Plasma Membrane Acetylcholine-gated Channel Complex Membrane Cation Channel Complex Neuron Projection Synapse Postsynaptic Membrane Synaptic Membrane Dopaminergic Synapse Presynapse Neurotransmitter Receptor Complex Cholinergic Synapse
	Molecular Function	Retinoic Acid Binding Retinoid Binding Fatty Acid Binding Protein Binding Lipid Binding Retinal Binding Retinol Binding	Transmembrane Signaling Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Protein Binding Ligand-gated Monoatomic Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine-gated Monoatomic Cation-selective Channel Activity
	Biological Process	Signal Transduction Fatty Acid Transport	Monoatomic Ion Transport Signal Transduction Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Neuromuscular Synaptic Transmission Monoatomic Ion Transmembrane Transport Response To Nicotine Behavioral Response To Nicotine Membrane Depolarization Regulation Of Postsynaptic Membrane Potential Excitatory Postsynaptic Potential Acetylcholine Receptor Signaling Pathway Presynaptic Modulation Of Chemical Synaptic Transmission
Pathways		RA biosynthesis pathway	Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors
Drugs			Nicotine Succinylcholine Butabarbital Cisatracurium Ethanol
Diseases
GWAS		Eyebrow thickness ( 26926045)	Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Airflow obstruction ( 22837378) Autism spectrum disorder or schizophrenia ( 28540026) Chronic obstructive pulmonary disease ( 28166215 33909500 22080838 20173748 19300482) Cotinine levels in smokers with chronic obstructive pulmonary disease ( 29631575) Diffusing capacity of carbon monoxide ( 30694715) Emphysema distribution in smoking ( 27669027) Emphysema imaging phenotypes ( 26030696) Exhaled carbon monoxide levels ( 25072098) Exhaled carbon monoxide levels in smokers with chronic obstructive pulmonary disease ( 29631575) Fagerstrӧm test for nicotine dependence ( 31294817) ICD10 Z72.0: Tobacco use ( 29758381) Local histogram emphysema pattern ( 25006744) Lung adenocarcinoma ( 19836008 28604730) Lung cancer ( 18385738 28604730 18780872 18385676 31577861 27393504) Lung cancer in ever smokers ( 28604730) Nicotine dependence ( 18385739 26440539) Non-small cell lung cancer ( 31326317) Parental lifespan ( 30642433 29030599) Parental longevity (both parents in top 10%) ( 29227965) Parental longevity (combined parental age at death) ( 29227965) Parental longevity (father's age at death) ( 29227965) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1 in COPD ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Pre bronchodilator FEV1 ( 26634245) Pre bronchodilator FEV1/FVC ratio ( 26634245) Pulmonary artery enlargement and chronic obstructive pulmonary disease ( 25101718) Pulmonary function ( 21946350) Schizophrenia ( 29483656 25056061) Serum albumin levels ( 23022100) Small cell lung carcinoma ( 28604730) Smoking behavior ( 22832964 20418889) Smoking behaviour (cigarettes smoked per day) ( 30679032) Smoking cessation ( 33082346) Smoking status (heavy vs light) ( 28520984) Time to smoke first cigarette in the morning ( 31294817) Urate levels ( 31578528) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		5 interacting genes: CFTR MPP3 NHERF1 TH TRA2A	1 interacting genes: CHRNB4
Entrez ID		1381	1138
HPRD ID		07520	00334
Ensembl ID		ENSG00000166426	ENSG00000169684
Uniprot IDs		F1T0F7 P29762	H0YM98 P30532 Q6EWN4
PDB IDs		7A9Y 7A9Z
Enriched GO Terms of Interacting Partners?		Chloride Channel Regulator Activity PDZ Domain Binding Neurotransmitter Receptor Complex Behavioral Response To Nicotine Trans-synaptic Signaling Synaptic Signaling Acetylcholine Receptor Activity Acetylcholine-gated Monoatomic Cation-selective Channel Activity Acetylcholine-gated Channel Complex Cation Channel Complex Synaptic Transmission, Cholinergic Cell-cell Signaling Ligand-gated Monoatomic Ion Channel Activity Neuromuscular Synaptic Transmission Extracellular Ligand-gated Monoatomic Ion Channel Activity Signaling Cell Communication Presynaptic Modulation Of Chemical Synaptic Transmission Response To Nicotine Acetylcholine Receptor Signaling Pathway Postsynaptic Signal Transduction Membrane Depolarization Chemical Synaptic Transmission Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Monoatomic Ion Transport Excitatory Postsynaptic Potential Synaptic Membrane Neuron Projection Tyrosine 3-monooxygenase Activity Dopamine Biosynthetic Process From Tyrosine Renal Phosphate Ion Absorption Apical Plasma Membrane Apical Part Of Cell Regulation Of Membrane Potential Positive Regulation Of Anion Channel Activity Regulation Of Postsynaptic Membrane Potential Epinephrine Biosynthetic Process Type 2 Metabotropic Glutamate Receptor Binding Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Transmembrane Transport Modulation Of Chemical Synaptic Transmission Animal Organ Morphogenesis Positive Regulation Of Monoatomic Anion Transport Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Serotonin Biosynthetic Process Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Pteridine As One Donor, And Incorporation Of One Atom Of Oxygen Type 3 Metabotropic Glutamate Receptor Binding	Synaptic Transmission Involved In Micturition Acetylcholine Receptor Activity Neurotransmitter Receptor Complex Behavioral Response To Nicotine Acetylcholine-gated Monoatomic Cation-selective Channel Activity Acetylcholine-gated Channel Complex Cation Channel Complex Synaptic Transmission, Cholinergic Ligand-gated Monoatomic Ion Channel Activity Neuromuscular Synaptic Transmission Extracellular Ligand-gated Monoatomic Ion Channel Activity Response To Nicotine Acetylcholine Receptor Signaling Pathway Postsynaptic Signal Transduction Membrane Depolarization Excitatory Postsynaptic Potential Regulation Of Smooth Muscle Contraction Synaptic Membrane Malonate-semialdehyde Dehydrogenase (acetylating) Activity Methylmalonate-semialdehyde Dehydrogenase (acylating, NAD) Activity Regulation Of Neurotransmitter Secretion Regulation Of Postsynaptic Membrane Potential Olfactory Lobe Development Thymine Metabolic Process Thymine Catabolic Process Adult Behavior Monoatomic Ion Channel Activity Regulation Of Acetylcholine Secretion, Neurotransmission Regulation Of Muscle Contraction L-valine Catabolic Process Locomotory Behavior Valine Metabolic Process Transmembrane Signaling Receptor Activity Positive Regulation Of Transmission Of Nerve Impulse Presynapse Postsynaptic Membrane Pyrimidine Nucleobase Catabolic Process Acetylcholine Binding Regulation Of Muscle System Process Response To Acetylcholine Retinal Binding Retinoid Binding Cholinergic Synapse Chemical Synaptic Transmission Retinol Binding Neuron Projection Trans-synaptic Signaling Synaptic Signaling Regulation Of Transmission Of Nerve Impulse Neuropilin Binding
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