CPN2 and CPN1

Number of citations of the paper that reports this interaction (PubMedID 14687935)
0

Data Source:
HPRD (in vitro)

		CPN2	CPN1
Description		carboxypeptidase N subunit 2	carboxypeptidase N subunit 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Extracellular Exosome Blood Microparticle	Extracellular Region Extracellular Space
	Molecular Function	Enzyme Regulator Activity Signaling Receptor Activity	Carboxypeptidase Activity Metallocarboxypeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Protein Stabilization	Proteolysis Peptide Metabolic Process Bradykinin Catabolic Process Protein Processing Protein Catabolic Process Response To Glucocorticoid
Pathways		Regulation of Complement cascade	Regulation of Complement cascade
Drugs		Zinc ORE-1001 Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Zinc ORE-1001 Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Triglyceride levels in HIV infection ( 33109212)	Blood protein levels ( 23696881) Creatine kinase levels ( 29403010) Dermatomyositis ( 27153935) Femoral neck bone mineral density ( 22504420) General cognitive ability ( 29844566) Heel bone mineral density ( 30598549) Height ( 20881960) Liver enzyme levels ( 18940312) Liver enzyme levels (alanine transaminase) ( 22001757) Mean reticulocyte volume ( 32888494)
Interacting Genes		1 interacting genes: CPN1	6 interacting genes: C3 C5 CDC42 CLEC4G CPN2 KNG1
Entrez ID		1370	1369
HPRD ID		11928	09120
Ensembl ID		ENSG00000178772	ENSG00000120054
Uniprot IDs		P22792	P15169
PDB IDs			2NSM
Enriched GO Terms of Interacting Partners?		Bradykinin Catabolic Process Metallocarboxypeptidase Activity Carboxypeptidase Activity Peptide Metabolic Process Metallopeptidase Activity Response To Glucocorticoid Response To Corticosteroid Protein Processing Response To Steroid Hormone	Complement Activation, Lectin Pathway Complement Activation, GZMK Pathway Blood Microparticle Killing Of Cells Of Another Organism Complement Activation, Alternative Pathway Cell Killing Positive Regulation Of Vascular Endothelial Growth Factor Production Leukocyte Migration Complement Activation, Classical Pathway Humoral Immune Response Regulation Of Vascular Endothelial Growth Factor Production Chemokine Activity Endopeptidase Inhibitor Activity Endoplasmic Reticulum Lumen Complement Activation Immune System Process Signaling Receptor Binding C5L2 Anaphylatoxin Chemotactic Receptor Binding Extracellular Exosome Immune Effector Process Virus Coreceptor Activity Extracellular Region Immune Response Positive Regulation Of Activation Of Membrane Attack Complex GBD Domain Binding Storage Vacuole Hormone Activity Inflammatory Response Complement-dependent Cytotoxicity Classical-complement-pathway C3/C5 Convertase Complex Receptor Ligand Activity Vertebrate Eye-specific Patterning Endothelin Receptor Signaling Pathway Involved In Heart Process Glycosylated Region Protein Binding Leukocyte Chemotaxis Oviduct Epithelium Development Positive Regulation Of Type IIa Hypersensitivity Complement-mediated Synapse Pruning Extracellular Space Apolipoprotein A-I Receptor Binding Neuropilin Signaling Pathway Positive Regulation Of Endocytosis Negative Regulation Of Immature T Cell Proliferation In Thymus Immature T Cell Proliferation In Thymus Cell Chemotaxis Regulation Of Multicellular Organismal Process Positive Regulation Of Complement Activation Positive Regulation Of Hypersensitivity Tissue Development G Protein-coupled Receptor Signaling Pathway
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