KCTD18 and ICA1L

		KCTD18	ICA1L
Description		potassium channel tetramerization domain containing 18	islet cell autoantigen 1 like
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Acrosomal Vesicle Cytoplasm Endomembrane System Secretory Granule Membrane
	Molecular Function	Identical Protein Binding	Protein Binding Protein Domain Specific Binding Membrane Curvature Sensor Activity
	Biological Process	Protein Homooligomerization	Spermatid Development Regulation Of Secretion Membrane Bending
Pathways
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Pelvic organ prolapse ( 26545240) Urinary albumin-to-creatinine ratio in non-diabetics ( 26631737)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Heel bone mineral density ( 28869591) Lacunar stroke ( 33773637) Mean platelet volume ( 32888494) Microalbuminuria ( 31511532) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377) Platelet count ( 32888494) Spontaneous coronary artery dissection ( 32887874) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Urinary albumin excretion ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 31511532) White matter hyperintensities ( 32358547) White matter integrity (fractional anisotropy) ( 32358547)
Interacting Genes		2 interacting genes: APP LRRK2	9 interacting genes: DPY30 GCC1 HGS KIFC3 KRT27 LMO2 MTDH RCOR3 TNPO3
Entrez ID		130535	130026
HPRD ID		08098	12447
Ensembl ID		ENSG00000155729	ENSG00000163596
Uniprot IDs		A8K4A2 Q6PI47	Q8NDH6 Q96Q33
PDB IDs
Enriched GO Terms of Interacting Partners?		Golgi-associated Vesicle Cellular Response To Catecholamine Stimulus Cellular Response To Manganese Ion Response To Catecholamine Response To Manganese Ion Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of CAMP/PKA Signal Transduction Modulation Of Excitatory Postsynaptic Potential Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Positive Regulation Of Tumor Necrosis Factor Production Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Calcium-mediated Signaling Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Regulation Of Nervous System Process Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Regulation Of Reactive Oxygen Species Metabolic Process Growth Cone Regulation Of Postsynapse Organization Perikaryon Acetylcholine Receptor Activator Activity Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Inflammatory Response Calcium-mediated Signaling Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Endocytosis Lipoprotein Particle Positive Regulation Of Protein Import Cellular Response To Metal Ion Negative Regulation Of Late Endosome To Lysosome Transport Amphisome Peroxidase Inhibitor Activity Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion Beta-catenin Destruction Complex Binding Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Neuron Differentiation Locomotory Behavior Positive Regulation Of Proteolysis Membrane Raft PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Reproductive Process
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