TYW5 and MARS2

		TYW5	MARS2
Description		tRNA-yW synthesizing protein 5	methionyl-tRNA synthetase 2, mitochondrial
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Mitochondrion Mitochondrial Matrix
	Molecular Function	TRNA Binding Iron Ion Binding Protein Binding Oxidoreductase Activity Protein Homodimerization Activity Metal Ion Binding Dioxygenase Activity TRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase Activity	Nucleotide Binding Aminoacyl-tRNA Ligase Activity Methionine-tRNA Ligase Activity ATP Binding Ligase Activity
	Biological Process	TRNA Processing Wybutosine Biosynthetic Process	Translation TRNA Aminoacylation For Protein Translation Methionyl-tRNA Aminoacylation
Pathways		Synthesis of wybutosine at G37 of tRNA(Phe)	Mitochondrial tRNA aminoacylation
Drugs
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) QT interval (sulfonylurea treatment interaction) ( 27958378) Schizophrenia ( 23974872 28991256 29483656) Sleep duration ( 30846698) Type 2 diabetes ( 25760438)	Autism spectrum disorder or schizophrenia ( 28540026) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Idiopathic dilated cardiomyopathy ( 29495422) Morning person ( 30696823) Schizophrenia ( 25056061 29483656) Stroke ( 32693751) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes			2 interacting genes: APP OGT
Entrez ID		129450	92935
HPRD ID		08232	14363
Ensembl ID		ENSG00000162971	ENSG00000247626
Uniprot IDs		A2RUC4	Q96GW9
PDB IDs		3AL5 3AL6
Enriched GO Terms of Interacting Partners?		Methionyl-tRNA Aminoacylation Methionine-tRNA Ligase Activity TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity TRNA Aminoacylation	Amyloid-beta Complex Regulation Of ATP Metabolic Process Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Regulation Of Glycolytic Process Amylin Binding Regulation Of Purine Nucleotide Metabolic Process Positive Regulation Of Toll Signaling Pathway Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly TRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase Activity Positive Regulation Of Proteolysis Acetylcholine Receptor Activator Activity PTB Domain Binding Regulation Of Synapse Assembly Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Endosome To Plasma Membrane Transport Vesicle Hemopoiesis Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Cell Development Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of Generation Of Precursor Metabolites And Energy Low-density Lipoprotein Particle Mediated Signaling Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein O-acetylglucosaminyltransferase Activity Ubiquinone Binding Wybutosine Biosynthetic Process Membrane Curvature Sensor Activity Membrane Bending Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway
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