TYW5

Description		tRNA-yW synthesizing protein 5
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GO Annotations	Cellular Component	Cytoplasm
	Molecular Function	TRNA Binding Iron Ion Binding Protein Binding Oxidoreductase Activity Protein Homodimerization Activity Metal Ion Binding Dioxygenase Activity TRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase Activity
	Biological Process	TRNA Processing Wybutosine Biosynthetic Process
Pathways		Synthesis of wybutosine at G37 of tRNA(Phe)
Drugs
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) QT interval (sulfonylurea treatment interaction) ( 27958378) Schizophrenia ( 23974872 28991256 29483656) Sleep duration ( 30846698) Type 2 diabetes ( 25760438)
Novel Interacting Genes		2 novel interacting genes: MARS2 SATB2-AS1
Interacting Genes
Entrez ID		129450
HPRD ID		08232
Ensembl ID		ENSG00000162971
Uniprot IDs		A2RUC4
PDB IDs		3AL5 3AL6
Enriched GO Terms of Interacting Partners?		Methionyl-tRNA Aminoacylation Methionine-tRNA Ligase Activity TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity TRNA Aminoacylation
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