ZPBP2 and PGAP3

		ZPBP2	PGAP3
Description		zona pellucida binding protein 2	post-GPI attachment to proteins phospholipase 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Zona Pellucida Receptor Complex Extracellular Region Nucleus Membrane Cytoplasmic Vesicle Cell Body	Golgi Membrane Endoplasmic Reticulum Membrane Golgi Apparatus Membrane
	Molecular Function		Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Ester Bonds
	Biological Process	Acrosome Assembly Negative Regulation Of Immunoglobulin Production Sphingolipid Metabolic Process Binding Of Sperm To Zona Pellucida Circadian Regulation Of Gene Expression Membrane Lipid Catabolic Process	GPI Anchor Metabolic Process GPI Anchor Biosynthetic Process
Pathways
Drugs
Diseases
GWAS		Adult asthma ( 30787307) Allergic rhinitis ( 30013184) Asthma ( 31959851 28461288 27182965 31619474) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 29273806) Asthma (time to onset) ( 27130862) Asthma or allergic disease (pleiotropy) ( 29785011) Atrial fibrillation ( 30061737 29892015) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908 21102463) Fractional exhaled nitric oxide (childhood) ( 24315451) Inflammatory bowel disease ( 28067908 23128233) Neurociticism ( 29500382) Primary biliary cholangitis ( 30643196 20639880 23000144) Primary biliary cirrhosis ( 22961000) Refractive error ( 32231278) Rheumatoid arthritis ( 30572963) Subcutaneous adipose tissue ( 27918534) Systemic sclerosis ( 30572963) Ulcerative colitis ( 28067908 21297633 20228799)	Asthma ( 29273806 31619474 31959851) Asthma or allergic disease (pleiotropy) ( 29785011) Liver enzyme levels (alkaline phosphatase) ( 33972514) Menopause (age at onset) ( 26414677) Pancreatic ductal adenocarcinoma ( 30541042) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 33547301) Triglyceride levels ( 30108155)
Interacting Genes
Entrez ID		124626	93210
HPRD ID		18365	15118
Ensembl ID		ENSG00000186075	ENSG00000161395
Uniprot IDs		Q6X784	A8K0P7 J3QKU0 Q96FM1
PDB IDs
Enriched GO Terms of Interacting Partners?			Regulation Of Protein Catabolic Process At Presynapse, Modulating Synaptic Transmission Presynaptic Modulation Of Chemical Synaptic Transmission SCF Ubiquitin Ligase Complex SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Behavioral Fear Response Multicellular Organismal Response To Stress Regulation Of Synaptic Vesicle Exocytosis Behavioral Defense Response Fear Response Circadian Regulation Of Gene Expression Binding Of Sperm To Zona Pellucida Membrane Lipid Catabolic Process Zona Pellucida Receptor Complex Acrosome Assembly Secretory Granule Organization Cell-cell Recognition Negative Regulation Of Immunoglobulin Production Sperm-egg Recognition Regulation Of Neurotransmitter Secretion Cell Body Regulation Of Immunoglobulin Production
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