EARS2 and DCTN5

		EARS2	DCTN5
Description		glutamyl-tRNA synthetase 2, mitochondrial	dynactin subunit 5
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Chromosome, Centromeric Region Kinetochore Nucleoplasm Chromosome Cytoplasm Centrosome Cytosol Cytoskeleton Dynactin Complex Nuclear Membrane
	Molecular Function	TRNA Binding Nucleotide Binding RNA Binding Aminoacyl-tRNA Ligase Activity Glutamate-tRNA Ligase Activity ATP Binding Zinc Ion Binding Ligase Activity Glutamate-tRNA(Gln) Ligase Activity	Protein Binding
	Biological Process	Translation TRNA Aminoacylation For Protein Translation Glutamyl-tRNA Aminoacylation TRNA Aminoacylation TRNA Aminoacylation For Mitochondrial Protein Translation	Ventricular Septum Development Aorta Development Coronary Vasculature Development
Pathways		Mitochondrial tRNA aminoacylation	MHC class II antigen presentation HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic
Drugs		Glutamic acid
Diseases
GWAS			Bipolar disorder ( 17554300)
Interacting Genes		1 interacting genes: OGT	5 interacting genes: DYNLL1 FATE1 NINL PMEPA1 RBPMS
Entrez ID		124454	84516
HPRD ID		11174	14551
Ensembl ID		ENSG00000103356	ENSG00000166847
Uniprot IDs		Q5JPH6	Q9BTE1
PDB IDs			5NW4
Enriched GO Terms of Interacting Partners?		Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein O-acetylglucosaminyltransferase Activity Dynactin Complex Regulation Of Transcription By Glucose NSL Complex Acetylglucosaminyltransferase Activity Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Histone Acetyltransferase Complex Sin3-type Complex Regulation Of Necroptotic Process Regulation Of Receptor Localization To Synapse Regulation Of Protein Localization To Synapse Regulation Of Rac Protein Signal Transduction Negative Regulation Of Stem Cell Population Maintenance Aorta Development Ventricular Septum Development Coronary Vasculature Development Phosphatidylinositol-3,4,5-trisphosphate Binding Cellular Response To Nutrient Regulation Of Programmed Necrotic Cell Death Mitophagy Protein Localization To Lysosome Circadian Regulation Of Gene Expression Positive Regulation Of Stem Cell Population Maintenance Cellular Response To Glucose Stimulus Regulation Of Stem Cell Population Maintenance Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Carbohydrate Catabolic Process Regulation Of Gluconeogenesis Regulation Of ATP Metabolic Process Regulation Of Glycolytic Process Positive Regulation Of TORC1 Signaling Cellular Response To Carbohydrate Stimulus Negative Regulation Of Translational Initiation Negative Regulation Of Proteasomal Protein Catabolic Process Pyroptotic Inflammatory Response Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Autophagy Of Mitochondrion Positive Regulation Of Translational Initiation Negative Regulation Of Protein Ubiquitination TORC1 Signaling Regulation Of Insulin Receptor Signaling Pathway Artery Development Cardiac Septum Development
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