DNAAF1 and KCNG4

		DNAAF1	KCNG4
Description		dynein axonemal assembly factor 1	potassium voltage-gated channel modifier subfamily G member 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Spindle Pole Extracellular Region Cytoplasm Cytoskeleton Cilium Axoneme Cell Projection	Nucleoplasm Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Monoatomic Ion Channel Complex
	Molecular Function	Dynein Complex Binding	Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity Potassium Channel Activity Potassium Channel Regulator Activity Transmembrane Transporter Binding
	Biological Process	Heart Looping Cilium Movement Regulation Of Cilium Beat Frequency Lung Development Axoneme Assembly Determination Of Pancreatic Left/right Asymmetry Outer Dynein Arm Assembly Inner Dynein Arm Assembly Motile Cilium Assembly Cilium Assembly Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Left/right Pattern Formation Axonemal Dynein Complex Assembly Determination Of Digestive Tract Left/right Asymmetry Determination Of Liver Left/right Asymmetry	Action Potential Monoatomic Ion Transport Potassium Ion Transport Monoatomic Ion Transmembrane Transport Regulation Of Potassium Ion Transport Protein Homooligomerization Transmembrane Transport Potassium Ion Transmembrane Transport Regulation Of Potassium Ion Transmembrane Transport
Pathways			Voltage gated Potassium channels
Drugs			Enflurane Promethazine Miconazole
Diseases		Primary ciliary dyskinesia, including: Primary ciliary dyskinesia; Kartagener syndrome
GWAS		Post bronchodilator FEV1/FVC ratio ( 26634245) Response to platinum-based neoadjuvant chemotherapy in cervical cancer ( 28120872) Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415)	Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Systolic blood pressure (baseline) ( 33603002) Visceral adipose tissue adjusted for BMI ( 22589738)
Interacting Genes			3 interacting genes: KCNB1 KCNE5 KCNF1
Entrez ID		123872	93107
HPRD ID		14023	16253
Ensembl ID		ENSG00000154099	ENSG00000168418
Uniprot IDs		A0A140VJN4 Q8NEP3	Q32MC1 Q547S7 Q8TDN1
PDB IDs
Enriched GO Terms of Interacting Partners?			Potassium Channel Regulator Activity Voltage-gated Potassium Channel Activity Voltage-gated Potassium Channel Complex Action Potential Potassium Ion Transmembrane Transport Potassium Ion Export Across Plasma Membrane Potassium Ion Transport Delayed Rectifier Potassium Channel Activity Regulation Of Membrane Potential Export Across Plasma Membrane Potassium Channel Activity Metal Ion Transport Regulation Of Potassium Ion Transport Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Inorganic Ion Transmembrane Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Monoatomic Ion Channel Complex Transmembrane Transporter Binding Monoatomic Ion Channel Activity Monoatomic Ion Transport Positive Regulation Of Norepinephrine Secretion Protein Homooligomerization Clustering Of Voltage-gated Potassium Channels Transmembrane Transport Determination Of Pancreatic Left/right Asymmetry Protein Complex Oligomerization Cilium Assembly Negative Regulation Of Potassium Ion Export Across Plasma Membrane Determination Of Liver Left/right Asymmetry Protein-containing Complex Assembly Positive Regulation Of Long-term Synaptic Depression Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Determination Of Digestive Tract Left/right Asymmetry Cilium Organization Proximal Dendrite Protein-containing Complex Organization Atrial Cardiac Muscle Cell Action Potential Regulation Of Norepinephrine Secretion Positive Regulation Of Catecholamine Secretion Regulation Of Transport Cholinergic Synapse Neuronal Ion Channel Clustering Plasma Membrane Bounded Cell Projection Assembly Cell Projection Assembly Regulation Of Metal Ion Transport Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization Regulation Of Potassium Ion Export Across Plasma Membrane
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