GSTO2 and KLHL10

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GSTO2	KLHL10
Description		glutathione S-transferase omega 2	kelch like family member 10
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome	Cytoplasm Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Glutathione Transferase Activity Protein Binding Oxidoreductase Activity Transferase Activity Identical Protein Binding Glutathione Dehydrogenase (ascorbate) Activity Methylarsonate Reductase Activity	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Glutathione Metabolic Process Xenobiotic Metabolic Process L-ascorbic Acid Metabolic Process Cellular Response To Arsenic-containing Substance Cellular Oxidant Detoxification	Cell Morphogenesis Spermatogenesis Spermatid Development Male Gonad Development Fertilization Protein Ubiquitination Cell Differentiation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Male Genitalia Morphogenesis Homeostasis Of Number Of Cells Within A Tissue
Pathways		Glutathione conjugation Vitamin C (ascorbate) metabolism
Drugs		Glutathione
Diseases
GWAS		Heel bone mineral density x serum urate levels interaction ( 34046847)	High light scatter reticulocyte count ( 32888494) Immature fraction of reticulocytes ( 32888494) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252)
Interacting Genes		11 interacting genes: CREBBP GCA HOXC8 INCA1 KLHL10 NTAQ1 PFDN5 POLR1C PWWP3A SMARCC1 TFAP2A	2 interacting genes: GSTO2 VHL
Entrez ID		119391	317719
HPRD ID		13614	12296
Ensembl ID		ENSG00000065621	ENSG00000161594
Uniprot IDs		B4DU59 Q9H4Y5	A0A140VJM8 B4DX37 Q6JEL2
PDB IDs		3Q18 3Q19 3QAG
Enriched GO Terms of Interacting Partners?			Methylarsonate Reductase Activity Glutathione Dehydrogenase (ascorbate) Activity Regulation Of Cellular Response To Hypoxia Transcription Elongation Factor Activity Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Amyloid Fibril Formation Negative Regulation Of Receptor Signaling Pathway Via STAT Negative Regulation Of DNA-templated Transcription, Elongation Protein Serine/threonine Kinase Binding Negative Regulation Of Transcription Elongation By RNA Polymerase II Glutathione Transferase Activity L-ascorbic Acid Metabolic Process Response To Arsenic-containing Substance Cellular Response To Arsenic-containing Substance
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