CIB3 and NANOS3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CIB3	NANOS3
Description		calcium and integrin binding family member 3	nanos C2HC-type zinc finger 3
Image			No pdb structure
GO Annotations	Cellular Component		P-body Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Stress Granule Perinuclear Region Of Cytoplasm
	Molecular Function	Magnesium Ion Binding Calcium Ion Binding Protein Binding Metal Ion Binding	RNA Binding MRNA Binding Protein Binding Enzyme Activator Activity Zinc Ion Binding Metal Ion Binding
	Biological Process	Calcium Ion Homeostasis	Regulation Of Translation Germ Cell Development Spermatogenesis Negative Regulation Of Translation Cell Differentiation Oogenesis Regulation Of Cell Cycle MRNA Destabilization Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway
Pathways			Specification of primordial germ cells
Drugs
Diseases
GWAS		Lymphocyte count ( 32888494)	Hand grip strength ( 29691431)
Interacting Genes		53 interacting genes: ARMC8 BEND7 C17orf50 ENOX2 GMCL1 KASH5 KLF17 LNX1 MEOX1 MEOX2 NANOS3 NME4 PAX5 PAX6 POLR2G POU6F2 RBAK REL SCNM1 SERTAD1 SLPI SP3 SP4 SYPL1 TACC3 TLE5 TRAF5 TRIM14 TRIM2 ZBTB43 ZC2HC1C ZFP1 ZFP57 ZNF146 ZNF177 ZNF180 ZNF19 ZNF276 ZNF317 ZNF329 ZNF398 ZNF426 ZNF552 ZNF559-ZNF177 ZNF578 ZNF597 ZNF620 ZNF664 ZNF688 ZNF774 ZNF835 ZSCAN4 ZSCAN5A	7 interacting genes: CIB3 CNOT1 IMP3 MLH1 PSMB1 SIAH1 TEKT4
Entrez ID		117286	342977
HPRD ID		16713	19428
Ensembl ID		ENSG00000141977	ENSG00000187556
Uniprot IDs		Q96Q77	P60323
PDB IDs		6WU5 6WU7 6WUD
Enriched GO Terms of Interacting Partners?		DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Zinc Ion Binding DNA Binding Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Metal Ion Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Sequence-specific Double-stranded DNA Binding Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Protein Binding DNA-binding Transcription Factor Activity RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Somite Specification DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Sequence-specific DNA Binding HMG Box Domain Binding Embryonic Camera-type Eye Morphogenesis Segment Specification Somite Development Chromatin	Nuclear-transcribed MRNA Poly(A) Tail Shortening Meiotic Spindle Midzone Assembly Macromolecule Catabolic Process Meiotic Metaphase Chromosome Alignment Male Meiosis Chromosome Segregation MutLalpha Complex Chiasma Nuclear-transcribed MRNA Catabolic Process Late Recombination Nodule MRNA Catabolic Process Meiotic Metaphase I Homologous Chromosome Alignment Mpp10 Complex Positive Regulation Of Isotype Switching To IgA Isotypes RNA Catabolic Process Guanine/thymine Mispair Binding MutSalpha Complex Binding Homologous Chromosome Segregation Female Meiosis Chromosome Segregation Regulation Of Mitotic Recombination Mismatch Repair Complex Negative Regulation Of Mitotic Recombination CCR4-NOT Core Complex Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Preribosome Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Armadillo Repeat Domain Binding Telomere Localization Spindle Midzone Assembly Mismatched DNA Binding Positive Regulation Of Isotype Switching To IgG Isotypes Catabolic Process Proteasome Core Complex, Beta-subunit Complex Beta-catenin Destruction Complex Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Poly(A)-specific Ribonuclease Activity Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Somatic Hypermutation Of Immunoglobulin Genes Meiotic Chromosome Segregation Somatic Diversification Of Immune Receptors Via Somatic Mutation Regulation Of Retinoic Acid Receptor Signaling Pathway Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway
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