ALPK2 and RAX

		ALPK2	RAX
Description		alpha kinase 2	retina and anterior neural fold homeobox
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Basolateral Plasma Membrane	Chromatin Nucleus
	Molecular Function	Protein Serine/threonine Kinase Activity ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Heart Morphogenesis Negative Regulation Of Wnt Signaling Pathway Involved In Heart Development Regulation Of Gene Expression Establishment Of Cell Polarity Regulation Of Apoptotic Process Cardiac Muscle Cell Development Epicardium Morphogenesis	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Pattern Specification Process Brain Development Visual Perception Hypothalamus Development Camera-type Eye Development Positive Regulation Of Transcription By RNA Polymerase II Limb Development
Pathways
Drugs
Diseases			Anophthalmia and microphthalmia (A/M)
GWAS		Alanine aminotransferase levels ( 33547301) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Diisocyanate-induced asthma ( 25918132) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Family history of Alzheimer's disease ( 30617256) HDL cholesterol levels ( 32203549) Hip circumference ( 28552196) Liver enzyme levels (alkaline phosphatase) ( 33972514) Metabolite levels ( 23823483) Multiple sclerosis ( 31604244 21833088) Multiple sclerosis and systolic blood pressure (pleiotropy) ( 26920376) Serum alkaline phosphatase levels ( 33547301) Triglyceride levels ( 32203549 32154731)	Chronotype ( 27494321) Macular thickness ( 30535121) Morning vs. evening chronotype ( 27494321) Triglyceride levels x thiazide or thiazide-like diuretics use interaction ( 31806883)
Interacting Genes			1 interacting genes: PAX6
Entrez ID		115701	30062
HPRD ID		11019	03530
Ensembl ID		ENSG00000198796	ENSG00000134438
Uniprot IDs		Q86TB3	Q9Y2V3
PDB IDs
Enriched GO Terms of Interacting Partners?			Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Negative Regulation Of Wnt Signaling Pathway Involved In Heart Development Forebrain Dorsal/ventral Pattern Formation Regulation Of Asymmetric Cell Division Forebrain Neuron Fate Commitment Habenula Development Oligodendrocyte Cell Fate Specification Ventral Spinal Cord Development Animal Organ Morphogenesis Pallium Development Formation Of Anatomical Boundary Iris Morphogenesis Glial Cell Fate Specification Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Cerebral Cortex Regionalization Lacrimal Gland Development Telencephalon Regionalization Epicardium Morphogenesis Type B Pancreatic Cell Differentiation Cornea Development In Camera-type Eye Salivary Gland Morphogenesis HMG Box Domain Binding Co-SMAD Binding Regulation Of Timing Of Cell Differentiation Negative Regulation Of Neuroblast Proliferation Dorsal/ventral Axis Specification Regulation Of Development, Heterochronic Embryonic Camera-type Eye Morphogenesis Enteroendocrine Cell Differentiation RNA Polymerase II Core Promoter Sequence-specific DNA Binding Cell Development Negative Regulation Of Developmental Process Negative Regulation Of Neural Precursor Cell Proliferation Histone Acetyltransferase Binding Embryonic Eye Morphogenesis R-SMAD Binding Positive Regulation Of Neuroblast Proliferation Gland Morphogenesis Pituitary Gland Development Astrocyte Differentiation Photoreceptor Cell Development Establishment Of Spindle Orientation Regulation Of Neuroblast Proliferation Lens Development In Camera-type Eye Signal Transduction Involved In Regulation Of Gene Expression Eye Photoreceptor Cell Development Transcription Coregulator Binding Neuron Fate Commitment Establishment Of Mitotic Spindle Localization
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