OSBPL6 and SHD

Number of citations of the paper that reports this interaction (PubMedID 25814554)
62

Data Source:
BioGRID (two hybrid)

		OSBPL6	SHD
Description		oxysterol binding protein like 6	Src homology 2 domain containing transforming protein D
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Cytoplasm Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Endosome Membrane Membrane Early Endosome Membrane Nuclear Membrane Perinuclear Endoplasmic Reticulum
	Molecular Function	Protein Binding Lipid Binding Cholesterol Binding Sterol Transfer Activity	Phosphotyrosine Residue Binding Protein Binding
	Biological Process	Bile Acid Biosynthetic Process Lipid Transport Sterol Transport Regulation Of Cholesterol Transport
Pathways		Synthesis of bile acids and bile salts
Drugs
Diseases
GWAS		Alzheimer disease and age of onset ( 26830138) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Gut microbiota alpha diversity (PD_whole_tree index) ( 33208821) Neuritic plaque ( 31497858) Rapid functional decline in sporadic amyotrophic lateral sclerosis ( 26746183) Refractive error ( 32231278) Smoking status (ever vs never smokers) ( 30643258)	Post-bronchodilator lung function in asthma (FVC) ( 32989782)
Interacting Genes		1 interacting genes: SHD	14 interacting genes: ABL1 BECN1 CAPN10 EGFR ERBB2 ERBB3 ERBB4 KRTCAP2 MET MRPS22 NCK2 OLIG1 OSBPL6 PSG11
Entrez ID		114880	56961
HPRD ID		09476	15337
Ensembl ID		ENSG00000079156	ENSG00000105251
Uniprot IDs		Q9BZF3	Q96IW2
PDB IDs
Enriched GO Terms of Interacting Partners?		Phosphotyrosine Residue Binding	Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Protein Tyrosine Kinase Activity Basal Plasma Membrane ERBB2 Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Epidermal Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Activity Response To Epidermal Growth Factor Neuron Differentiation Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Programmed Cell Death Receptor Complex ERBB3:ERBB2 Complex Protein Kinase Activity Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Cellular Response To Growth Factor Stimulus Negative Regulation Of Programmed Cell Death Response To Growth Factor Regulation Of Apoptotic Process Kinase Activity ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Epithelial Cell Proliferation ERBB2-EGFR Signaling Pathway Glial Cell Development Positive Regulation Of Cell Communication Positive Regulation Of MAPK Cascade Positive Regulation Of Signaling Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB4 Signaling Pathway Negative Regulation Of Apoptotic Process Basolateral Plasma Membrane Regulation Of Rho Protein Signal Transduction Positive Regulation Of Cell Population Proliferation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Animal Organ Development Regulation Of Intracellular Signal Transduction Regulation Of ERK1 And ERK2 Cascade Endosome Membrane Protein Tyrosine Kinase Activator Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Glial Cell Differentiation Schwann Cell Development Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Signal Transduction
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