PRRT2 and ZNF689

		PRRT2	ZNF689
Description		proline rich transmembrane protein 2	zinc finger protein 689
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Synaptic Vesicle Membrane Axon Synaptic Vesicle Membrane Cytoplasmic Vesicle Vesicle Presynaptic Membrane Cell Projection Dendritic Spine Axon Terminus Synapse Postsynaptic Membrane Presynapse Postsynaptic Density Membrane Glutamatergic Synapse	Nucleus Cytoplasm
	Molecular Function	Protein Binding Syntaxin-1 Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Histone Binding Metal Ion Binding
	Biological Process	Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Negative Regulation Of SNARE Complex Assembly Neuromuscular Process Controlling Posture Regulation Of Calcium-dependent Activation Of Synaptic Vesicle Fusion Negative Regulation Of Short-term Synaptic Potentiation	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Skeletal Muscle Cell Differentiation
Pathways			Generic Transcription Pathway
Drugs
Diseases
GWAS			Heel bone mineral density ( 30598549)
Interacting Genes		8 interacting genes: AQP6 F2RL1 GPRC5D SLC10A6 SLC71A2 SMIM5 SNAP25 TLCD4	4 interacting genes: HNRNPF HNRNPU NCL TRIM28
Entrez ID		112476	115509
HPRD ID		13995	14009
Ensembl ID		ENSG00000167371	ENSG00000156853
Uniprot IDs		Q7Z6L0	Q96CS4
PDB IDs
Enriched GO Terms of Interacting Partners?			Spliceosomal Complex Regulation Of RNA Splicing Ribonucleoprotein Complex Single-stranded RNA Binding Catalytic Step 2 Spliceosome Cellular Response To Leukemia Inhibitory Factor Inactive Sex Chromosome Poly(C) RNA Binding Promoter-specific Chromatin Binding Cytoplasmic Ribonucleoprotein Granule RNA Localization To Chromatin Response To Leukemia Inhibitory Factor Regulation Of MRNA Splicing, Via Spliceosome Protein Localization To Spindle Microtubule Macropinosome Membrane Krueppel-associated Box Domain Binding Negative Regulation Of Short-term Synaptic Potentiation Negative Regulation Of SNARE Complex Assembly Regulation Of Calcium-dependent Activation Of Synaptic Vesicle Fusion RNA Binding TFIIH-class Transcription Factor Complex Binding Dendritic Transport Of Messenger Ribonucleoprotein Complex Regulation Of MRNA Processing Heterochromatin Formation Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity RNA Polymerase II Transcription Regulator Complex Ubiquitin-like Protein Ligase Activity Negative Regulation Of Gene Expression, Epigenetic DNA Topoisomerase Binding Embryonic Placenta Morphogenesis Negative Regulation Of Vesicle Fusion MRNA Splicing, Via Spliceosome Transcription Corepressor Activity CRD-mediated MRNA Stability Complex Convergent Extension Involved In Axis Elongation Chromo Shadow Domain Binding RNA Splicing, Via Transesterification Reactions PiRNA Binding RNA Polymerase II C-terminal Domain Binding Poly(G) Binding Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore PH Domain Binding Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Mitotic Spindle Midzone CRD-mediated MRNA Stabilization Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Epigenetic Regulation Of Gene Expression Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Vesicle Fusion To Plasma Membrane
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