FSTL1 and SGCA

Number of citations of the paper that reports this interaction (PubMedID 28514442)
50

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, two hybrid)

		FSTL1	SGCA
Description		follistatin like 1	sarcoglycan alpha
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Extracellular Exosome	Golgi Membrane Cytoplasm Endoplasmic Reticulum Membrane Cytoskeleton Plasma Membrane Cell-cell Junction Dystrophin-associated Glycoprotein Complex Dystroglycan Complex Sarcoglycan Complex Membrane Sarcolemma Membrane Raft
	Molecular Function	Calcium Ion Binding Protein Binding Heparin Binding	Calcium Ion Binding Protein Binding
	Biological Process	Cell Differentiation Regulation Of BMP Signaling Pathway Negative Regulation Of Apoptotic Process Endothelial Cell Migration Endothelial Cell Differentiation Hematopoietic Stem Cell Homeostasis	Muscle Contraction Muscle Organ Development
Pathways		Signaling by BMP Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)
Drugs
Diseases			Limb-girdle muscular dystrophy (LGMD) Sarcoglycanopathies, including: Limb-girdle muscular dystrophy (LGMD) 2C; Limb-girdle muscular dystrophy (LGMD) 2D; Limb-girdle muscular dystrophy (LGMD) 2E; Limb-girdle muscular dystrophy (LGMD) 2F
GWAS		Blood protein levels ( 30072576) Obesity-related traits ( 23251661)	Heel bone mineral density ( 30598549) Keratoconus ( 33649486) Temporomandibular joint disorder ( 28081371) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		6 interacting genes: APPBP2 CRK MTNR1A MTNR1B SGCA SGTA	8 interacting genes: FN1 FSTL1 ITGB1BP2 SGCB SGCD SGTA SGTB TAF1
Entrez ID		11167	6442
HPRD ID		16120	02525
Ensembl ID		ENSG00000163430	ENSG00000108823
Uniprot IDs		Q12841	A0A0S2Z4P8 A0A0S2Z4Q1 Q16586
PDB IDs
Enriched GO Terms of Interacting Partners?		Melatonin Receptor Activity G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger	TRC Complex Sarcoglycan Complex Dystroglycan Complex Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Muscle Organ Development Dystrophin-associated Glycoprotein Complex Muscle Structure Development Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Cardiac Muscle Cell Development Cardiac Cell Development Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Androgen Receptor Signaling Pathway Protein Targeting To Membrane Striated Muscle Cell Development Response To Activity Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Endothelial Cell Migration Negative Regulation Of Protein Autoubiquitination Microtubule Nucleator Activity Muscle Cell Development Negative Regulation Of Monocyte Activation Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Identical Protein Binding Sarcolemma Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Calcium-independent Cell-matrix Adhesion BAT3 Complex Binding Acetyl-CoA Binding Positive Regulation Of Proteolysis Involved In Protein Catabolic Process RNA Polymerase I General Transcription Initiation Factor Activity Histone H4K16ac Reader Activity Polar Microtubule Negative Regulation Of Proteolysis
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