SDS and IFT81

		SDS	IFT81
Description		serine dehydratase	intraflagellar transport 81
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol	Cytoplasm Centrosome Centriole Microtubule Organizing Center Cytoskeleton Cilium Intraciliary Transport Particle B Motile Cilium Ciliary Basal Body Cell Projection Sperm Midpiece Sperm Principal Piece Ciliary Tip
	Molecular Function	L-serine Ammonia-lyase Activity Threonine Deaminase Activity Protein Binding Lyase Activity Pyridoxal Phosphate Binding Protein Homodimerization Activity	Protein Binding Tubulin Binding
	Biological Process	Gluconeogenesis Amino Acid Metabolic Process L-serine Catabolic Process Lipid Metabolic Process Pyruvate Biosynthetic Process Small Molecule Biosynthetic Process	Spermatogenesis Regulation Of Smoothened Signaling Pathway Cell Projection Organization Cell Differentiation Intraciliary Anterograde Transport Intraciliary Transport Involved In Cilium Assembly Intraciliary Transport Cilium Assembly Sperm Flagellum Assembly
Pathways		Threonine catabolism Serine metabolism	Intraflagellar transport Intraflagellar transport
Drugs		Pyridoxal phosphate Serine
Diseases
GWAS		Body mass index ( 26426971) Low high density lipoprotein cholesterol levels ( 26879886)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 31043756) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Headache ( 29397368) Intelligence (MTAG) ( 29326435) Total intracranial volume ( 31530798)
Interacting Genes		3 interacting genes: DDI1 HGS TGM7	2 interacting genes: APP HUNK
Entrez ID		10993	28981
HPRD ID		01633	09266
Ensembl ID		ENSG00000135094	ENSG00000122970
Uniprot IDs		P20132 Q8WW81	Q8WYA0
PDB IDs		1P5J 4H27
Enriched GO Terms of Interacting Partners?			Protein Homodimerization Activity Acetylcholine Receptor Activator Activity Protein-folding Chaperone Binding Amyloid-beta Complex PTB Domain Binding Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Response To Calcium Ion Regulation Of Establishment Of Protein Localization Axon Midline Choice Point Recognition Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Lymphocyte Migration Lipoprotein Particle Regulation Of Protein Transport Growth Factor Receptor Binding Main Axon Regulation Of Mononuclear Cell Migration Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Dendritic Spine Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Regulation Of Secretion Regulation Of Secretion By Cell L-serine Ammonia-lyase Activity Threonine Deaminase Activity L-serine Catabolic Process Pyruvate Biosynthetic Process Sodium Ion Transmembrane Transport Intracellularly Phosphatidylinositol-3,5-bisphosphate-gated Monatomic Cation Channel Activity Voltage-gated Channel Activity NAADP-sensitive Calcium-release Channel Activity NatB Complex Calcium:sodium Antiporter Activity Involved In Regulation Of Cardiac Muscle Cell Membrane Potential Calcium:sodium Antiporter Activity Calcium:monoatomic Cation Antiporter Activity
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