LMAN2 and TSPAN17

		LMAN2	TSPAN17
Description		lectin, mannose binding 2	tetraspanin 17
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Plasma Membrane Cell Surface Membrane COPII-coated ER To Golgi Transport Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Extracellular Exosome	Plasma Membrane Membrane
	Molecular Function	Protein Binding D-mannose Binding Carbohydrate Binding Heat Shock Protein Binding Metal Ion Binding	Enzyme Binding
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Protein Transport Positive Regulation Of Phagocytosis	Intracellular Protein Localization Regulation Of Membrane Protein Ectodomain Proteolysis Establishment Of Protein Localization To Organelle
Pathways		COPII-mediated vesicle transport Cargo concentration in the ER
Drugs
Diseases
GWAS		Activated partial thromboplastin time ( 22703881) Allergic disease (asthma, hay fever or eczema) ( 29083406) Anthropometric traits ( 30166351) Anthropometric traits (multi-trait analysis) ( 30166351) Blood protein levels ( 30072576) Chronic kidney disease ( 20383146) High light scatter reticulocyte count ( 32888494) Red blood cell count ( 27863252) Reticulocyte count ( 32888494) Serum uric acid levels ( 30993211) Triglyceride levels ( 32203549) Urinary calcium excretion ( 31993563) Waist circumference adjusted for body mass index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		4 interacting genes: ATP13A2 FRAT1 MAPK9 SUPT5H
Entrez ID		10960	26262
HPRD ID		17285	18198
Ensembl ID		ENSG00000169223	ENSG00000048140
Uniprot IDs		A0A384NPY7 Q12907	J3KNG2 Q96FV3
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Catabolic Process JUN Kinase Activity Protein Localization To Tricellular Tight Junction DSIF Complex Regulation Of Intracellular Protein Transport Polyamine Transmembrane Transporter Activity Spermine Transport Extracellular Exosome Biogenesis P-type Transmembrane Transporter Activity Spermine Transmembrane Transport ABC-type Polyamine Transporter Activity Cellular Response To Oxidative Stress Regulation Of Macroautophagy Extracellular Vesicle Biogenesis P-type Ion Transporter Activity Negative Regulation Of Lysosomal Protein Catabolic Process Regulation Of Autophagosome Size Cupric Ion Binding Polyamine Transmembrane Transport Cellular Response To Chemical Stress Regulation Of Intracellular Transport Regulation Of Chaperone-mediated Autophagy Cellular Response To Manganese Ion Positive Regulation Of Podosome Assembly ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Regulation Of Lysosomal Protein Catabolic Process Inflammatory Response To Wounding Response To Metal Ion Regulation Of Podosome Assembly Response To Manganese Ion Autophagosome-lysosome Fusion MAP Kinase Activity Response To Oxidative Stress Regulation Of Proteolysis Regulation Of Autophagy Positive Regulation Of Exosomal Secretion Enzyme Binding Protein Localization To Cell-cell Junction Regulation Of Exosomal Secretion Positive Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Protein Metabolic Process Regulation Of Protein Transport Cellular Response To Zinc Ion	Positive Regulation Of Phagocytosis D-mannose Binding Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum COPII-coated ER To Golgi Transport Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Heat Shock Protein Binding Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Regulation Of Phagocytosis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Positive Regulation Of Endocytosis Carbohydrate Binding
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