PMVK and ZNF559-ZNF177

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PMVK	ZNF559-ZNF177
Description		phosphomevalonate kinase	ZNF559-ZNF177 readthrough
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Peroxisome Cytosol Membrane Extracellular Exosome	Nucleus Blood Microparticle
	Molecular Function	Nucleotide Binding Phosphomevalonate Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Steroid Metabolic Process Cholesterol Metabolic Process Sterol Biosynthetic Process Isopentenyl Diphosphate Biosynthetic Process, Mevalonate Pathway Response To Cholesterol	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II
Pathways		Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP)
Drugs
Diseases
GWAS		Atrial fibrillation ( 22544366 29892015) Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) HDL cholesterol ( 24097068) HDL cholesterol levels ( 28334899) Inflammatory bowel disease ( 27569725) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Prostate cancer ( 23535732)
Interacting Genes		4 interacting genes: DDIT4L MCPH1 ZNF177 ZNF559-ZNF177	17 interacting genes: BOLA2 BOLA2B CIB3 CSNK2A1 CT55 EXOC8 LMO1 MID2 MLH1 PMVK PRKAB2 PRKAR1B PSMB1 SNAP25 SNAPC5 TRAF4 ZGPAT
Entrez ID		10654	100529215
HPRD ID		07404
Ensembl ID		ENSG00000163344	ENSG00000270011
Uniprot IDs		Q15126 Q6FGV9
PDB IDs		3CH4
Enriched GO Terms of Interacting Partners?		Blood Microparticle Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Chromosome Condensation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Sequence-specific Double-stranded DNA Binding Neuronal Stem Cell Population Maintenance Establishment Of Mitotic Spindle Orientation Protein Localization To Centrosome Regulation Of Transcription By RNA Polymerase II Establishment Of Spindle Orientation Establishment Of Mitotic Spindle Localization	Iron-sulfur Cluster Assembly Complex [2Fe-2S] Cluster Assembly 2 Iron, 2 Sulfur Cluster Binding Iron-sulfur Cluster Assembly
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