PITRM1 and IDI1

		PITRM1	IDI1
Description		pitrilysin metallopeptidase 1	isopentenyl-diphosphate delta isomerase 1
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Cytoplasm Peroxisome Cytosol
	Molecular Function	Metalloendopeptidase Activity Protein Binding Enzyme Activator Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding	Magnesium Ion Binding Isopentenyl-diphosphate Delta-isomerase Activity Protein Binding Isomerase Activity Intramolecular Oxidoreductase Activity Manganese Ion Binding Metal Ion Binding
	Biological Process	Proteolysis Protein Targeting To Mitochondrion Protein Processing	Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Steroid Metabolic Process Cholesterol Metabolic Process Isoprenoid Biosynthetic Process Isopentenyl Diphosphate Biosynthetic Process Sterol Biosynthetic Process Response To Stilbenoid Dimethylallyl Diphosphate Biosynthetic Process
Pathways		Mitochondrial protein import	Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP)
Drugs			Dimethylallyl Diphosphate
Diseases
GWAS		Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Metabolite levels ( 23823483) Scalp hair shape ( 26926045)
Interacting Genes			5 interacting genes: BARD1 BCL2L13 TXNIP WT1 ZNF655
Entrez ID		10531	3422
HPRD ID		07142	07235
Ensembl ID		ENSG00000107959	ENSG00000067064
Uniprot IDs		A0A0A0MRX9 A0A7I2V397 Q5JRX3	A0A8Q3WKR8 Q13907
PDB IDs		4L3T 4NGE 4RPU 6XOS 6XOT 6XOU 6XOV 6XOW	2DHO 2I6K 2ICJ 2ICK
Enriched GO Terms of Interacting Partners?		Protein Targeting To Mitochondrion	Positive Regulation Of Programmed Cell Death BRCA1-B Complex Regulation Of Programmed Cell Death Histone H2AK127 Ubiquitin Ligase Activity Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Histone H2AK129 Ubiquitin Ligase Activity Negative Regulation Of MRNA 3'-end Processing BRCA1-BARD1 Complex Hemi-methylated DNA-binding Negative Regulation Of Female Gonad Development Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation Negative Regulation Of Glomerular Mesangial Cell Proliferation Adrenal Cortex Formation Positive Regulation Of Metanephric Ureteric Bud Development Metanephric S-shaped Body Morphogenesis Visceral Serous Pericardium Development Posterior Mesonephric Tubule Development Cellular Response To Tumor Cell BRCA1-A Complex Nuclear Ubiquitin Ligase Complex Negative Regulation Of Protein Export From Nucleus BRCA1-C Complex Negative Regulation Of Mitotic Cell Cycle Phase Transition Ubiquitin-modified Histone Reader Activity Negative Regulation Of Mitotic Cell Cycle Diaphragm Development Negative Regulation Of Cell Proliferation Involved In Kidney Development Regulation Of Female Gonad Development Thorax And Anterior Abdomen Determination Positive Regulation Of Male Gonad Development S-shaped Body Morphogenesis Cardiac Muscle Cell Fate Commitment Double-stranded Methylated DNA Binding Metanephric Mesenchyme Development Positive Regulation Of 3'-UTR-mediated MRNA Stabilization Negative Regulation Of Cell Cycle Phase Transition Regulation Of MRNA 3'-end Processing Zinc Ion Binding Regulation Of RNA Metabolic Process Negative Regulation Of Cell Cycle Process Nucleolus Nephron Tubule Morphogenesis Podocyte Differentiation Glomerular Basement Membrane Development Regulation Of Glomerular Mesangial Cell Proliferation Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process DNA Strand Resection Involved In Replication Fork Processing Metanephric Epithelium Development
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